Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent
Zhumakova S. Tokusheva A. Zharkynbek T. Balabekova M. Koks S. Seilkhanov T. Dembitsky V. Zazybin A. Aydemir M. Kemelbekov U. Kairanbayeva G. Yu V.
November 2024Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2024#29Issue 21
The synthesized compound, 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP), and its 1:1 complex with β-cyclodextrin (EPPPβCD) have been characterized for the first time through a comprehensive suite of analytical methods. This study explores the therapeutic potential of EPPPβCD in modulating immune responses and accelerating the resolution of septic inflammation induced by chromium and vanadium ions in outbred male rats. The research highlights the significant impact of EPPPβCD on the dynamics of regulatory T lymphocytes (Tregs), notably causing a reduction in the CD4+CD25+ fractions at the onset of inflammation. This effect is attributed to the inhibition of Treg proliferation, which is crucial in hastening the resolution of inflammation. These findings underscore the potential of EPPPβCD as a promising therapeutic agent in controlling and mitigating inflammation mediated by heavy metal exposure, thereby offering a new avenue for the development of anti-inflammatory treatments.
1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP) , ammonium vanadate (NH4VO3) , aseptic inflammation , complex EPPP with β-cyclodextrin (EPPPβCD) , heavy metal technology-related exposure , potassium bichromate (K2Cr2O7) , supracomplex
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Laboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences, 106 Sh. Ualikhanov St., Almaty, 050010, Kazakhstan
School of Chemical Engineering, Kazakh-British Technical University, 59 Tole bi St., Almaty, 050000, Kazakhstan
Department of Pathological Physiology, Asfendiyarov Kazakh National Medical University, 94 Tole-bi St., Almaty, 050000, Kazakhstan
Health Futures Institute, Murdoch University, 90 South St., Perth, 6150, WA, Australia
Laboratory of Engineering Profile of NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, 76 Abai St., Kokshetau, 020000, Kazakhstan
Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College, 3000 College Drive South, Lethbridge, T1K 1L6, AB, Canada
Department of Chemistry, Faculty of Science, Dicle University, Diyarbakir, 21280, Turkey
South Kazakhstan Medical Academy, 1 Al-Farabi Square, Shymkent, 160019, Kazakhstan
Laboratory of Synthetic and Natural Medicinal Compounds Chemistry
School of Chemical Engineering
Department of Pathological Physiology
Health Futures Institute
Laboratory of Engineering Profile of NMR Spectroscopy
Centre for Applied Research
Department of Chemistry
South Kazakhstan Medical Academy
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