Modern concepts of the molecular genetic markers of prostate cancer
Zhumakayev A.M. Benberin V.V. Shanazarov N.A. Tuleutaev M.E. Seydalin N.K. Davranov A.Zh. Zhumakayeva A.M. Muratov T.M. Kasymov B.G.
2021Tomsk National Research Medical Center of the Russian Academy of Sciences
Siberian Journal of Oncology
2021#20Issue 5162 - 169 pp.
Purpose of the study: to present up-to-date data on molecular genetic studies aimed to identify the risks of developing prostate cancer in representatives of various ethnic groups. Material and Methods. Literary sources were searched in databases such as PubMed, Medline, Google Scholar. We had analyzed 60 sources on the risks of developing prostate cancer. The epidemiological data on the prostate cancer incidence and risk factors depending on age characteristics, hormonal status and hereditary predisposition were shown. Results. The pathogenetic features of prostate cancer depending on ethnicity were described. The paper presents data from both European and Asian ethnic groups. In a number of studies, significant genetic differences in single nucleotide polymorphisms associated with the development of prostate cancer were identified. Conclusion. Research in the field of determining the risks of developing prostate cancer becomes more and more relevant due to the emergence of new molecular genetic markers, as well as the influence of various ethnic characteristics. Nevertheless, many questions of modern diagnosis of prostate cancer are still open, therefore, research in this area remains promising.
Ethnic characteristics , Genetic markers , Hereditary predisposition , Prostate cancer , Risk factors , Single nucleotide polymorphisms (SNP)
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