STUDIES ON THE BIOLOGICAL ACTIVITY OF DIFFERENT POPULATIONS OF THE MEDICINAL PLANT RHODIOLA ROSEA L. (GOLDEN ROOT)
Zhumagul M. Kurmanbayeva M. Kubentayev S. Kurmantayeva A. Turgumbayeva A. Nurpeissova I. Cherepkova N. Moldakaryzova A.
2023Pakistan Botanical Society
Pakistan Journal of Botany
2023#55Issue 51857 - 1865 pp.
Rhodiola rosea species have a wide spectrum of therapeutic action and are actively used as a tonic, adaptogenic, antidepressant, anti-inflammatory, and for other treatments. We analyzed the phytochemical composition of essential oils of R. rosea from the high mountainous regions of Kazakhstan Altai (Eastern Kazakhstan) and Austria. The results showed high percentages of cinnamyl alcohol (31.28%), Cyclobutanecarboxylic acid, 3-methylbutyl ester (9.65%) (9.65%) in the roots of R. rosea. of Kazakhstan Altai and the content of cinnamyl alcohol (27.28%), Tyrosol in the root (19.39%) native to Hochkar, Austrian Alps. The antioxidant activity and cytotoxicity of species of different populations of R. rosea were also studied. The results revealed antioxidant activity of this species. Biologically active compounds of R. rosea have many pharmaceutical effects in various diseases. The formula of essential oils from the root of R. rosea were analyzed using GC-MS. The antioxidative activity was determined by FRAP method. The essential oil has shown a low antioxidative activity compared to butylhydroxyanisole(BHA)at concentrations of 0.25-1.0 mg ml-1, which confirms the antioxidative properties of this species. The results of cytotoxic activity against the larvae of Artemia salina has revealed that its essential oil shows lethal toxicity at all tested concentrations, proving the cytoxicity of golden root.
Antioxidative activity , Biological activity , Cytotoxic activity , Rhodiola rosea
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Al-Farabi Kazakh National University, Almaty, Kazakhstan
Astana Botanical Garden, branch of the Republican State Enterprise on the right of economic management, Institute of Botany and Phytoinroduction, Nur-Sultan, Kazakhstan
Republican state enterprise on the right of economic management Institute of Botany and Phytointroduction of the Committee of Forestry and Wildlife of the Ministry of Ecology, Geology and Natural Resources of the Republic of Kazakhstan, Almaty, Kazakhstan
S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Al-Farabi Kazakh National University
Astana Botanical Garden
Republican state enterprise on the right of economic management Institute of Botany and Phytointroduction of the Committee of Forestry and Wildlife of the Ministry of Ecology
S.D. Asfendiyarov Kazakh National Medical University
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