PHARMACOLOGICAL EVALUATION OF RHODIOLA ROSEA L. EXTRACT FROM THE KAZAKH ECOSYSTEM: IMPLICATIONS FOR OBESITY MANAGEMENT IN MALE RATS
Zhumagul М. Rašeta M. Mišković J. Myrzagaliyeva A.B. Kurmanbayeva M. Gafforov Y. Kubentayev S.A. Kobylina T. Shaikhymbekova R. Kusmangazinov A.
2024Romanian Society for Pharmaceutical Sciences
Farmacia
2024#72Issue 1104 - 115 pp.
The aim of the study was to conduct a comprehensive assessment of the pharmacotherapeutic effect of the extract R. rosea in obesity including GC-MS analysis, biochemical analysis of blood serum and open field test were also conducted. The purebred 3-month-old white male laboratory rats were divided into three groups, control and two experimental groups with alimentary obesity with and without R. rosea treatment and fed with a low-calorie diet. Body weight decreased significantly with concomitant administration of R. rosea extract in the third group, whereas active weight loss was observed from 263.39 ± 10.80 g on day 25 to 213.34 ± 8.74 g on day 30. Treatment with R. rosea extract reduced total body weight, abdominal fat mass, and lipids. The character of the pathological process was established in the rats with obesity after the application of R. rosea normalized the rats liver enzyme levels. The open field test showed that the rats treated with R. rosea extract had a pronounced resistance of the nervous system and a moderate level of autonomic and emotional behaviour. The obtained results suggest that R. rosea extract should be used against obesity due to its anti-adipogenic properties.
lipids , medicinal plant , obesity , Rhodiola rosea
Text of the article Перейти на текст статьи
Department Al-Farabi, Kazakh National University, Al-Farabi Avenue, 71/19, Almaty, 050060, Kazakhstan
“Astana Botanical Garden” Branch of the Republican State Enterprise on the Right of Economic Management “Institute of Botany and Phytoinroduction”, Orynbor 16, Astana, 010016, Kazakhstan
Astana International University, Qabanbay Batyr Ave 8, Astana, 020000, Kazakhstan
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, 21000, Serbia
Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 2, Novi Sad, 21000, Serbia
New Uzbekistan University, 54 Mustaquillik Ave., Tashkent, 100007, Uzbekistan
Central Asian University, Tashkent, 111221, Uzbekistan
Institute of Botany, Academy of Sciences of Republic of Uzbekistan, 32 Durmon Yuli, Tashkent, 100125, Uzbekistan
Institute of Genetic and Physiology, prospect Al-Farabi, 93, Bostandyk district, 050060/A15E3K2, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Tole by 94, Almaty, 050012, Kazakhstan
Department Al-Farabi
“Astana Botanical Garden” Branch of the Republican State Enterprise on the Right of Economic Management “Institute of Botany and Phytoinroduction”
Astana International University
Department of Chemistry
Department of Biology and Ecology
New Uzbekistan University
Central Asian University
Institute of Botany
Institute of Genetic and Physiology
Asfendiyarov Kazakh National Medical University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026