Bacterial vaginosis and disorders of blood and lymph circulation in the pelvic organs: is there any connection?

Zhukembaeva A.M. Lokshin V.N. Issenova S.S.
2025 Dynasty Publishing House

Voprosy Ginekologii, Akusherstva i Perinatologii
2025 #24 Issue 3 100 - 104 pp.

Objective. To analyze data from recent publications on the causes of bacterial vaginosis (BV) and to study the possibility of developing vaginal dysbiosis in the presence of disorders of blood and lymph circulation in the pelvic organs. A search for scientific publications over a five-year period was conducted in the following databases: PubMed, Scopus, Wiley, Medline, Google Scholar, and Web of Science. Various combinations of terms were used: bacterial vaginosis, microbiota, vaginal dysbiosis, varicose veins, venous and lymphatic insufficiency. The search was conducted by key words using MESH. Inclusion criteria: publications with evidence levels A and B. Exclusion criteria: commercial articles and informational notes. The search was limited to humans, language restrictions were “English” and “Russian,” the search was also limited to full-text papers only, abstracts were excluded, and there were no restrictions on article availability (all sources can be requested from authors). Case reports, case series, and reviews were excluded. The authors used the “snowball” method based on lists of references to articles, including reviews, to find additional studies. The effect of pelvic varicose veins on the vaginal biocenosis was studied. The significance of inflammatory diseases of the internal genitalia in the development of venous and lymphatic pathology in the small pelvis in women was demonstrated. Inflammatory processes are considered one of the significant factors that induce the development of varicose veins (VV), chronic venous insufficiency (CVI), and venous and lymphatic insufficiency (VLI). The latter is of particular importance. Any inflammatory process, regardless of its localization, involves the lymphatic system and microcirculatory bed and can spread upward, affecting regional lymph nodes and vessels in the form of lymphadenitis and lymphangitis, as well as the venous system with the development of thrombophlebitis and/or phlebothrombosis. Conclusion. BV in women with disorders of blood and lymph circulation in the pelvic organs is an extremely relevant issue, with many unresolved questions of both a scientific and practical nature that require experimental and clinical studies aimed at investigating new data on the etiopathogenesis of BV.

bacterial vaginosis , microbiota , vaginal dysbiosis , varicose veins , venous and lymphatic insufficiency

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Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
International Clinical Center for Reproductive Medicine “PERSONA”, Almaty, Kazakhstan
Center of Perinatology and Pediatric Cardiac Surgery, Almaty, Kazakhstan

Asfendiyarov Kazakh National Medical University
International Clinical Center for Reproductive Medicine “PERSONA”
Center of Perinatology and Pediatric Cardiac Surgery

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