68GA-FAPI PET/CT IN DIAGNOSIS OF THE BREAST CANCER DEPENDING ON THE MOLECULAR SUBTYPES AND EXPRESSION STATUS OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2/NEU)
Zholdybay Z. Zhakenova Z. Gabdullina M. Filippenko Y. Yessentayeva S. Alisherov G. Mustapaeva A. Amankulov J. Fakhradiyev I.
1 July 2025
Georgian medical news
2025Issue 364-365355 - 363 pp.
This study evaluates the diagnostic potential of 68Ga-FAPI PET/CT in women with newly diagnosed breast cancer (BC), with an emphasis on molecular subtypes and HER2/neu expression status. A total of 34 patients (median age: 55.5 years; range: 26-80) with histologically confirmed invasive BC underwent 68Ga-FAPI PET/CT prior to initiating treatment. Tumors were classified according to immunohistochemical markers (ER, PR, HER2/neu, Ki-67) into Luminal A, Luminal B (HER2-negative and HER2-positive), and triple-negative subtypes. A total of 46 malignant lesions were identified, including multicentric tumors in 9 patients. The highest FAPI uptake (SUVmax and TBR) was observed in HER2-positive tumors, particularly Luminal B HER2-positive subtypes. Statistically significant differences in FAPI uptake and TBR were found between tumors with HER2 overexpression and those with HER2-zero expression (p = 0.015). The study demonstrates that 68Ga-FAPI PET/CT may enhance diagnostic accuracy in aggressive BC phenotypes, particularly HER2-overexpressing tumors, and could serve as a valuable complementary imaging modality for staging and treatment planning.
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1S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
1S.D. Asfendiyarov Kazakh National Medical University, Almaty; 2Al-Farabi Kazakh National University, Faculty of Medicine and Healthcare, Almaty, Kazakhstan
3Kazakh-Russian Medical University, Oncology and Radiology Department, Almaty, Kazakhstan
1S.D. Asfendiyarov Kazakh National Medical University, Almaty; 4Limited Liability Company HiLife, Department of Nuclear Medicine, Almaty, Kazakhstan
1S.D. Asfendiyarov Kazakh National Medical University, Almaty; 5Kazakh Oncology Institute, Radiology and Nuclear medicine Centre, Almaty, Kazakhstan
1S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan; 6College of Medicine, Korea University, Seoul, South Korea
1S.D. Asfendiyarov Kazakh National Medical University
1S.D. Asfendiyarov Kazakh National Medical University
3Kazakh-Russian Medical University
1S.D. Asfendiyarov Kazakh National Medical University
1S.D. Asfendiyarov Kazakh National Medical University
1S.D. Asfendiyarov Kazakh National Medical University
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