ApoE Gene Polymorphism and Clinical, Biochemical, and Sociodemographic Characteristics of Alzheimers Disease Patients From Northern and Southern Regions of Kazakhstan
Zholdasbekova G. Kaiyrlykyzy A. Kassenova A. Alzhanova D. Klyuev D. Askarova S.
November 2024John Wiley and Sons Ltd
International Journal of Geriatric Psychiatry
2024#39Issue 11
Background: Alzheimers disease (AD) is the most frequent cause of dementia in seniors and is also one of the critical social issues of modern healthcare. Since AD is considered a multifactorial disease, the significance of particular risk factors in different ethnic populations is constantly reevaluated. Method: The study group consisted of 181 patients with AD, and the control group included 244 healthy seniors comparable in sex and age to the dementia group. Our study compared clinical data, blood biochemical parameters, various sociodemographic characteristics, and ApoE gene polymorphism in patients diagnosed with AD from Kazakhstans north (Astana city) and south (Almaty city) regions. Results: In our cohort, significant dementia-associated variables included smoking, clinically significant depression, dyslipidemia, impaired glucose metabolism, insulin resistance, and liver dysfunction. Notably, AD patients had higher HDL levels, lower ALT levels, and higher total bilirubin and AST/ALT ratios. The ApoE ɛ4 genotype, a well-known AD risk factor, was more prevalent in the northern AD group. Additionally, participants from Astana city had a higher incidence of strokes, potentially linked to elevated LDL levels, while Almaty city residents exhibited a higher prevalence of clinically severe depression. Discussion: These findings underscore the importance of considering bio-geographic and environmental factors in AD research. The studys outcomes may aid in further research and the development of personalized approaches for managing and treating AD in distinct geographical regions.
Alzheimers , ApoE gene polymorphism , blood biochemical parameters , comorbid diseases , dementia
Text of the article Перейти на текст статьи
Institute for Life Sciences, Medical University of Karaganda, Karaganda, Kazakhstan
Laboratory of Bioengineering and Regenerative Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
Graduate School of Public Health, al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Neurology, Astana Medical University, Astana, Kazakhstan
Institute for Life Sciences
Laboratory of Bioengineering and Regenerative Medicine
Graduate School of Public Health
Department of Neurology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026