Functional Properties of Enriched Curd with Collagen and Plant Phytochemicals for Athletes and Physiological Benefits: Evidence Data from Preclinical Trials In Vivo
Zharykbasova K. Kakimov A. Zharykbasov Y. Kakimova Z. Guldana R. Zhanna K. Galiya B. Baigazinov Z. Kovács T. Shahrokhi A.
November 2025Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients
2025#17Issue 21
Background/Objectives: The aim of this study was to establish the multifactorial physiological effect of a functional curd product enriched with collagen-containing concentrate and phytochemical extracts of various natures, under conditions of in vivo experiment. Methods: Biomarkers, such as antioxidant activity (glutathione peroxidase, glutathione reductase, MDA), immune response (IgA, IgG, IgM, IL-6, TNF-α), and purine metabolism (uric acid, xanthine oxidase, 5′-nucleotidase) were selected for evaluation and their influence change. The model was white outbred rats (n = 45), randomly distributed into three groups: control (basic product), experimental group 1 (supplements of collagen-containing concentrate and extract of the composition of sea buckthorn and rosehips), and experimental group 2 (supplements of collagen-containing concentrate and extract of the composition of yarrow and sage). Results: In both experimental groups, a reliable increase in the enzymatic activity of the antioxidant system, a decrease in lipid peroxidation and the level of proinflammatory cytokines, an increase in immunoglobulins, and activation of 5′-nucleotidase were observed. The most pronounced effects were observed with the introduction of a curd product containing collagen-containing concentrate and sea buckthorn and rosehip extract. Conclusions: The scientific novelty of the study lies in the first comprehensive in vivo evaluation of the combined enrichment of a dairy product with collagen and plant extracts for a set of biomarkers. The data obtained confirm the physiological activity and functional properties of the developed product, which can be considered as a promising means of specialized and sports nutrition with proven biological action.
collagen-containing concentrate , cottage cheese product , functional foods , in vivo experiment , phytochemical extracts , sports nutrition
Text of the article Перейти на текст статьи
Department of Applied Biology, Alikhan Bokeikhan University, Semey, 070000, Kazakhstan
Department of Technological Equipment, Shakarim University, Semey, 071412, Kazakhstan
Department of Biotechnology, Shakarim University, Semey, 071412, Kazakhstan
Department of Physiological Disciplines Named After T.A. Nazarova, NCJSC, Semey Medical University, Semey, 070000, Kazakhstan
JSC “Park of Nuclear Technologies”, Kurchatov, 071100, Kazakhstan
Research Centre for Biochemical, Environmental and Chemical Engineering, University of Pannonia, Veszprem, 8200, Hungary
Department of Applied Biology
Department of Technological Equipment
Department of Biotechnology
Department of Physiological Disciplines Named After T.A. Nazarova
JSC “Park of Nuclear Technologies”
Research Centre for Biochemical
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026