Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications
Zhantleuova A. Leese C. Andreou A.P. Karimova A. Carpenter G. Davletov B.
April 2024Multidisciplinary Digital Publishing Institute (MDPI)
Toxins
2024#16Issue 4
This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox or el-iBoNT, offer an alternative for patients who face limitations in using paralytic forms of botulinum neurotoxin due to concerns about muscle function loss. We highlight the research findings that confirm not only the effectiveness of these molecules but also their reduced paralytic effect. We also discuss a potential cause for the diminished paralytic action of these molecules, specifically changes in the spatial parameters of the new botulinum molecules. In summary, this article reviews the current research that enhances our understanding of the application of new botulinum neurotoxins in the context of common conditions and suggests new avenues for developing more efficient molecules.
botulinum neurotoxin , efficacy , non-paralytic molecules , safety , treatment
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Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Almaty, A15E3C7, Kazakhstan
Department of Biomedical Science, University of Sheffield, Sheffield, S10 2JA, United Kingdom
Headache Research, Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, SE1 1UL, United Kingdom
Neuresta, Inc., San Diego, 91991, CA, United States
Salivary Research, Centre for Host-Microbiome Interactions, Faculty of Dental, Oral & Craniofacial Sciences, King’s College London, London, SE1 1UL, United Kingdom
Department of Biophysics
Department of Biomedical Science
Headache Research
Neuresta
Salivary Research
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