NIR-ultraviolet encoded transmission-deep penetration nanobomb for nanobubble boosting tumors treatment
Zhang L. Aigerim T. Dong Y. Du Y. Gao R. Gulziya T. Songgula G. Xie Y. Qiao L. Tong F.
5 February 2026Elsevier B.V.
Colloids and Surfaces A: Physicochemical and Engineering Aspects
2026#730
Objective Tumor treatment mainly relied on surgery, combined with radiotherapy and drug chemotherapy, with limited treatment options. In the past few decades, the progress made in these treatment methods had limited impact on the overall survival of patients. Herein, we introduced a successful fabrication of biocompatible NIR-ultraviolet encoded transmission-deep penetration nanobomb (DPN) for nanobubble boosting active treatment of Tumors cells in vitro . Methods Aminofunctionalized mesoporous silica (NH2-MSNs) as the mainstay loaded ytterbium/thulium (Yb/Tm) doped strontium titanate (SrTiO3), chlorin e6 (Ce6) was plugged onto the surface via electrostatic interaction, functioning as a trigger for the controlled release of hydrogen/oxygen (H2/O2). Asymmetrical released H2/O2 took charge of synergistically with endogenous current/reactive oxygen species (ROS) nanobomb fuel to destroy tumor cell in vitro and supplementally worked as the impetus for the movement of the nanobombs. Key results after 808 nm laser irradiation, nanobombs generated electronic transitions and endogenous current/ROS, and formed endogenous ultraviolet light to hydrolyze and produced H2/O2, and the reaction between Yb/Tm and water also produced a large amount of H2, leading to therapeutic role to tumor cell in vitro . Conclusion the engineered nanobombs systems, with NIR-ultraviolet encoded transmission of movement behavior and H2/O2/ROS high-energy fuel release accompanied with endogenous current, displaying obvious promise as a potential platform for tumor cell treatment in vitro based on regulating tumor mitosis.
Current , Mitosis , Nanobomb , ROS , Tumor
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Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
Clinical Medical College, Binzhou Medical University, Yantai, 264003, China
Department of Pharmacology
Department of Biology
Clinical Medical College
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026