Safety of new tuberculosis treatment regimens and compliance with these regimens according to data from the Republic of Kazakhstan
Безопасность новых режимов профилактического лечения туберкулеза и приверженность к их соблюдению по данным Республики Казахстан
Zhandauletova Zh.T. Nikishova E.I. Maryandyshev A.O. Serikbaeva K.S. Adenov M.M. Ismailov Sh.Sh. Sapieva Zh.A. Trusov A.A. Musabekova G.A. Kasymbekova S.Zh. Rakisheva A.S.
2023New Terra Publishing House
Tuberculosis and Lung Diseases
2023#101Issue 117 - 26 pp.
The objective: to assess the safety and compliance with new regimens for preventive treatment of drug susceptible and drug resistant tuberculosis. Subjects and Methods. The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high risk of developing active tuberculosis received preventive tuberculosis treatment with new regimens: 71 patients were treated with isoniazid and rifampicin for 3 months (3 HR), 55 - with isoniazid and rifapentine for 1 month (1 HR), 56 - with levofloxacin for 6 months (6 Lfx). Results. During treatment with regimens 3 HR, 1 HP, 6 Lfx, no adverse events of severity degree 3-4 developed, while adverse events of severity degree 1-2 were rare and relieved. The patient-oriented approach to the organization of preventive chemotherapy made it possible to achieve high treatment completion rates: in the group receiving 3 HR, it was 97.2% of cases, in the group receiving 1 HP - 96.4%, and in the group receiving 6 Lfx - 82.2%.
new regimens , preventive treatment of tuberculosis
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National Research Center of Phthisiopulmonology, Ministry of Health of the Kazakhstan Republic, Almaty, Kazakhstan
Project Implementation Group, Global Fund to Fight AIDS, Tuberculosis and Malaria, Almaty, Kazakhstan
Northern (Arctic) Federal University named after M. V. Lomonosov, Arkhangelsk, Russian Federation
Public Foundation MAD Consulting, Almaty, Kazakhstan
Northern State Medical University, Arkhangelsk, Russian Federation
Phthisiopulmonology Center, Almaty, Kazakhstan
Kazakh Scientific Center of Dermatology and Infectious Diseases, Ministry of Health of the Kazakhstan Republic, Almaty, Kazakhstan
Kazakh National Medical University named after S. D. Asfendiyarov, Almaty, Kazakhstan
National Research Center of Phthisiopulmonology
Project Implementation Group
Northern (Arctic) Federal University named after M. V. Lomonosov
Public Foundation MAD Consulting
Northern State Medical University
Phthisiopulmonology Center
Kazakh Scientific Center of Dermatology and Infectious Diseases
Kazakh National Medical University named after S. D. Asfendiyarov
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