Parallel fiber-optic semi-distributed biosensor for detection of IL-6 and IL-8 cancer biomarkers in saliva at femtomolar limit
Zhakypbekova A. Bekmurzayeva A. Blanc W. Tosi D.
November 2025Elsevier Ltd
Optics and Laser Technology
2025#189
Biomarker-based diagnostics offer a promising approach for early cancer detection, while simultaneous analysis of multiple biomarkers can further improve disease diagnosis by enhancing sensitivity and specificity of the detection. This work presents a multi-resonance analysis strategy for the simultaneous detection of oral cancer biomarkers interleukin-6 and interleukin-8 in artificial saliva with a Fiber-Bragg grating-assisted semi-distributed interferometer-based probe. The analysis of the sensor response takes advantage of the entire spectral feature, which enhances the robustness and reliability of the detection results. Unlike single-feature approaches, multi-resonance analysis ensures greater resilience to spectral distortions, since the spectral features of the proposed sensor exhibit varying sensitivity to biomolecular interactions. The sensor demonstrated a limit of detection (LoD) of 480 aM for IL-6 and 23.4 fM for IL-8 in artificial saliva with high specificity to target proteins.
Biomarker detection , IL-6 , IL-8 , Multi-resonance analysis , Optical biosensor , OSCC , Point-of-care diagnostics , Semi-distributed interferometer , Surface functionalization
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School of Engineering and Digital Sciences, Nazarbayev University, Astana, Kazakhstan
Laboratory of Biosensors and Bioinstruments, National Laboratory Astana, Astana, Kazakhstan
Université Côte dAzur, CNRS, INPHYNI, France
School of Engineering and Digital Sciences
Laboratory of Biosensors and Bioinstruments
Université Côte dAzur
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026