Optimal tactics for surgical revascularisation in diabetic angiopathy of the lower limbs

Zhakubayev M. Yegemberdiyev T.Zh. Tolegen A.I. Tajibayev T.
July 2024 Wydawnictwo Aluna

Polski Merkuriusz Lekarski
2024 #52 Issue 4 415 - 420 pp.

Aim: This study aims to compare the efficacy of conservative treatment methods versus advanced surgical interventions, including revascularising automyelotransplantation and stem cell therapy, in improving vascular patency and the quality of life in patients with diabetic angiopathy. Materials and Methods: The research analyzed 68 patients with angiopathies under medical supervision from January 2007 to December 2017 at the National Scientific Center of Surgery named after A.N. Syzganov. Participants, aged 4 to 49, were divided into two groups based on angiographic blood flow characteristics: one with accelerated and another with delayed blood flow. A comprehensive participant selection process was implemented to ensure a representative sample. Sensitivity analysis was conducted to validate the findings’ robustness. Results: The main group demonstrated notable success in limb salvage, with 90.9% avoiding high limb amputation post-revascularising automyelotransplantation. Moreover, 16.7% of patients experienced healing of trophic ulcers and toe necrosis. The use of stem cells from adipose tissue and fetal tissue progenitor cells showed promising results in reducing pain and increasing pain-free walking distance, alongside the formation of collateral vascular networks. Conclusions: The study concludes that advanced surgical interventions and stem cell therapies significantly enhance treatment outcomes in patients with diabetic angiopathy compared to conventional conservative treatments. These findings highlight the potential of personalized and innovative approaches in managing vascular complications associated with diabetes, offering new avenues for reducing disability and improving patient quality of life. Future research should focus on further refining these therapeutic strategies and exploring their integration into clinical practice.

diabetes mellitus , diabetic angiopathy , indirect revascularisation , ischaemia , necrosis , trophic ulcers

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NATIONAL SCIENTIFIC CENTER OF SURGERY NAMED AFTER A.N. SYZGANOV, ALMATY, Kazakhstan
ASFENDIYAROV KAZAKH NATIONAL MEDICAL UNIVERSITY, ALMATY, Kazakhstan
PRIVATE CLINIC MEDITERRA, ALMATY, Kazakhstan

NATIONAL SCIENTIFIC CENTER OF SURGERY NAMED AFTER A.N. SYZGANOV
ASFENDIYAROV KAZAKH NATIONAL MEDICAL UNIVERSITY
PRIVATE CLINIC MEDITERRA

10 лет помогаем публиковать статьи Международный издатель

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