Osteoarthritis: A contemporary view of the problem, the possibilities of therapy and prospects for further research
Zaripova L. Tazhibayeva D. Kabdualieva N. Aitbayeva Z. Beglarova G. Yermentayeva L. Niyazbekova K.
2022National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2022#19Issue 66 - 12 pp.
Osteoarthritis is a chronic degenerative disease characterized by the destructive changes in the articular cartilage, synovitis, subchondral bone sclerosis and osteophyte formation. Today it is the most common joint disease and one of the main causes of disability of elderly people. This review provides an overview of advances in understanding of osteoarthritis etiology, pathogenesis, histopathology, as well as the results of up-to-date research of the molecular mechanisms underlying this heterogeneous age-related disease at the clinical and fundamental levels. The article is devoted to a comprehensive review of the osteoarthritis problem, compiled considering the classical understanding of morphological changes, clinical picture, diagnostic methods, and current therapy protocols, supplemented by the modern trends of world research with the prospect of further development and implementation of the latest therapeutic methods, such as nerve growth factor-inhibitors, fibroblast growth factor-18 and stem cells treatments.
biological therapy , osteoarthritis , pathogenesis , therapy , up-to-date research
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Scientific and Innovation Management Department, National Scientific Medical Center, Astana, Kazakhstan
Department of Pathological Physiology named after V.G.Korpachev, Astana Medical University, Astana, Kazakhstan
Scientific and Innovation Management Department
Department of Pathological Physiology named after V.G.Korpachev
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026