A Bibliometric and In Silico-Based Analysis of Anti-Lung Cancer Compounds from Sea Cucumber
Zare A. Izanloo S. Khaledi S. Maratovich M.N. Kaliyev A.A. Abenova N.A. Rahmanifar F. Mahdipour M. Bakhshalizadeh S. Shirazi R. Tanideh N. Tamadon A.
May 2023MDPI
Marine Drugs
2023#21Issue 5
Lung cancer is one of the most lethal malignancies in the world. However, current curative approaches for treating this type of cancer have some weaknesses. Therefore, scientists are attempting to discover new anti-lung cancer agents. Sea cucumber is a marine-derived source for discovering biologically active compounds with anti-lung cancer properties. To explore the anti-lung cancer properties of sea cucumber, we analyzed surveys using VOSviewer software and identified the most frequently used keywords. We then searched the Google Scholar database for compounds with anti-lung cancer properties within that keyword family. Finally, we used AutoDock 4 to identify the compounds with the highest affinity for apoptotic receptors in lung cancer cells. The results showed that triterpene glucosides were the most frequently identified compounds in studies examining the anti-cancer properties of sea cucumbers. Intercedenside C, Scabraside A, and Scabraside B were the three triterpene glycosides with the highest affinity for apoptotic receptors in lung cancer cells. To the best of our knowledge, this is the first time that anti-lung cancer properties of sea cucumber-derived compounds have been examined in in silico conditions. Ultimately, these three components displayed anti-lung cancer properties in in silico conditions and may be used for the manufacture of anti-lung cancer agents in the near future.
anti-cancer agents , apoptosis , bibliometrics , glucosides , in silico techniques , lung neoplasms , marine biology , sea cucumbers , triterpenes
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The PerciaVista Biotechnology Company, Shiraz, 71676-83745, Iran
Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, 14496-14535, Iran
School of Nursing, North Khorasan University of Medical Sciences, Bojnurd, 94149-74877, Iran
Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 14117-13116, Iran
General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030019, Kazakhstan
Department of Internal Diseases, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030019, Kazakhstan
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, 71348-14336, Iran
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, 51666-53431, Iran
Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, 51666-53431, Iran
Reproductive Development, Murdoch Children’s Research Institute, Melbourne, 3052, VIC, Australia
Department of Paediatrics, University of Melbourne, Melbourne, 3010, VIC, Australia
Department of Anatomy, School of Medical Sciences, Biomedical & Health, UNSW Sydney, Sydney, 1466, NSW, Australia
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran
Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran
Department for Scientific Work, Ospanov Medical University, West Kazakhstan Marat, Aktobe, 030010, Kazakhstan
The PerciaVista Biotechnology Company
Department of Anatomical Sciences
School of Nursing
Department of Anatomy
General Surgery
Department of Internal Diseases
Department of Basic Sciences
Stem Cell Research Center
Department of Applied Cell Sciences
Reproductive Development
Department of Paediatrics
Department of Anatomy
Stem Cells Technology Research Center
Department of Pharmacology
Department for Scientific Work
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