Naphthaleneoxypropargyl-Containing Piperazine as a Regulator of Effector Immune Cell Populations upon an Aseptic Inflammation

Yu V.K. Sycheva Y.S. Kairanbayeva G.K. Dembitsky V.M. Balabekova M.K. Tokusheva A.N. Seilkhanov T.M. Zharkynbek T.Y. Balapanova A.K. Tassibekov K.S.
October 2023 Multidisciplinary Digital Publishing Institute (MDPI)

Molecules
2023 #28 Issue 20

This study investigated the effects of aseptic inflammation and heavy metal exposure on immune responses, as well as the potential immunomodulatory properties of the newly synthesized 1-[1-(2,5-dimethoxyphenyl)-4-(naphthalene-1-yloxy)but-2-ynyl]-4-methylpiperazine complexed with β-cyclodextrin (β-CD). Aseptic inflammation was induced by a subcutaneous injection of turpentine in rats, while heavy metal exposure was achieved through a daily administration of cadmium chloride and lead acetate. The levels of immune cell populations, including cytotoxic T lymphocytes (CTL), monocytes, and granulocytes, were assessed in the spleen. The results showed that aseptic inflammation led to decreased levels of CTL, monocytes, and granulocytes on the 14th day, indicating an inflammatory response accompanied by a migration of effector cells to the inflamed tissues. The exposure to cadmium chloride and lead acetate resulted in systemic immunotoxic effects, with reduced levels of B cells, CD4⁺ Th cells, monocytes, and granulocytes in the spleen. Notably, piperazine complexed with β-CD (the complex) exhibited significant stimulatory effects on CD4⁺, CD8⁺, and myeloid cell populations during aseptic inflammation, even in the presence of heavy metal exposure. These findings suggest the potential immunomodulatory properties of the complex in the context of aseptic inflammation and heavy metal exposure.

1-[1-(2,5-dimethoxyphenyl)-4-(naphthalene-1-yloxy)but-2-ynyl]-4-methylpiperazine , aseptic inflammatiofn , cadmium chloride (CdCl₂) , heavy metal exposure , immune cell populations , lead acetate (Pb(CH₃COO)₂) , β-cyclodextrin

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A.B. Bekturov Institute of Chemical Sciences, 106 Sh. Ualikhanov St, Almaty, 050010, Kazakhstan
Pathological Physiology Department, Asfendiyarov Kazakh National Medical University, 94 Tole-bi St, Almaty, 050000, Kazakhstan
Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College, 3000 College Drive South, Lethbridge, T1K 1L6, AB, Canada
Laboratory of Engineering Profile NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, 76 Abai St, Kokshetau, 020000, Kazakhstan

A.B. Bekturov Institute of Chemical Sciences
Pathological Physiology Department
Centre for Applied Research
Laboratory of Engineering Profile NMR Spectroscopy

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