Hormonal Implications of SARS-CoV-2: A Review of Endocrine Disruptions
Yskak A. Sokharev Y. Zhumalynov K. Koneva E. Afanasyeva N. Borodulin D. Babaskin D. Nugmanov A. Nurushev M. Chashkov V.
2025John Wiley and Sons Ltd
Scientifica
2025#2025Issue 1
To improve medical care and rehabilitation algorithms for patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is important to evaluate and summarize the available data on the effect of coronavirus infection (COVID-19) on the endocrine system. The purpose of this review was to study the effect of COVID-19 on the endocrine system. The scientific novelty of this study is the evaluation of the effect of coronavirus infection on the endocrine system and the potential effect of hormones on susceptibility to COVID-19. The results of this review show that the endocrine system is vulnerable to disorders caused by COVID-19, mainly thyroid dysfunction and hyperglycemia. The information in the published literature mentioned here contains some unclear aspects and contradictory data, but much remains to be studied and clarified regarding the impact of COVID-19 on the endocrine system. In particular, this concerns the study of the hyperglycemic status of patients who have had coronavirus infection, which is extremely important for the future metabolic health of COVID-19 survivors. This review contributes to the scientific discourse by systematically synthesizing disparate studies to identify patterns, gaps, and emerging trends in the literature concerning the effects of COVID-19 on the endocrine system. By integrating these findings, this study offers a novel perspective on potential hormonal interactions influencing COVID-19 susceptibility and outcomes, proposing new hypotheses and frameworks for future research. Copyright
atividade funcional , coronavirus infection , endocrine system , functional activity , infeção por coronavírus , sistema endócrino
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Research Institute of Applied Biotechnology Akhmet Baitursynuly, Kostanay Regional University Kostanay Kazakhstan, KAZ, Kazakhstan
Faculty of Soil Science Lomonosov, Moscow State University Moscow Russia msu.ru, RUS, Russian Federation
Pathological Anatomy Department Municipal State Company, Kostanay Regional Pathoanatomical Bureau” of the Health, Department of the Akimat of the Kostanay Region Kostanay Kazakhstan, KAZ, Kazakhstan
Department of Natural Sciences Akhmet Baitursynuly, Kostanay Regional University Kostanay Kazakhstan, KAZ, Kazakhstan
Department of Sports Medicine and Medical Rehabilitation, Sechenov University Moscow Russia sechenov.ru, RUS, Russian Federation
Resource Center “Medical Sechenov Pre, University” Sechenov University Moscow Russia sechenov.ru, RUS, Russian Federation
Department of Technology of Storage and Processing of Fruits Vegetables and Plant Growing Products, Russian State Agrarian University-Moscow Timiryazev Agricultural Academy Moscow Russia, RUS, Russian Federation
Department of Pharmacy, Sechenov University Moscow Russia sechenov.ru, RUS, Russian Federation
Higher School of Natural Sciences, Astana International University Astana Kazakhstan, KAZ, Kazakhstan
Research Institute of Applied Biotechnology Akhmet Baitursynuly
Faculty of Soil Science Lomonosov
Pathological Anatomy Department Municipal State Company
Department of Natural Sciences Akhmet Baitursynuly
Department of Sports Medicine and Medical Rehabilitation
Resource Center “Medical Sechenov Pre
Department of Technology of Storage and Processing of Fruits Vegetables and Plant Growing Products
Department of Pharmacy
Higher School of Natural Sciences
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