Angiopoietin as a Novel Prognostic Marker in Kidney Disease
Yildiz A.B. Copur S. Tanriover C. Yavuz F. Vehbi S. Gaipov A. Magagnoli L. Ciceri P. Cozzolino M. Kanbay M.
23 January 2024S. Karger AG
Blood Purification
2024#53Issue 6425 - 435 pp.
Introduction: Renal injury is among the leading causes of morbidity and mortality; however, there are no reliable indicators for determining the likelihood of developing chronic kidney disease (CKD), CKD progression, or AKI events. Vascular growth factors called angiopoietins have a role in endothelial function, vascular remodeling, tissue stabilization, and inflammation and have been implicated as prognostic and predictive markers in AKI. Methods: Although the exact mechanism of the relationship between kidney injury and angiopoietins is unknown, this review demonstrates that AKI patients have higher angiopoietin-2 levels and that higher angiopoietin-1 to angiopoietin-2 ratio may potentially be linked with a reduced risk of the CKD progression. Results: This review therefore emphasizes the importance of angiopoietin-2 and proposes that it could be an important predictor of AKI in clinical settings. Conclusion: There is a need for further large-scale randomized clinical trials in order to have a better understanding of the significance of angiopoietin-2 and for the determination of its potential clinical implications.
Acute kidney injury , Angiopoietin , Chronic kidney disease , Kidney disease progression
Text of the article Перейти на текст статьи
Department of Medicine, Koc University School of Medicine, Istanbul, Turkey
Department of Medicine, Nazarbayev Unive Mario Cozzolino Rsity School of Medicine, Astana, Kazakhstan
Clinical Academic Department of Internal Medicine, Cf University Medical Center, Astana, Kazakhstan
Department of Health Sciences, Renal Division, University of Milan, Milan, Italy
Department of Medicine, Nephrology, Koc University School of Medicine, Istanbul, Turkey
Department of Medicine
Department of Medicine
Clinical Academic Department of Internal Medicine
Department of Health Sciences
Department of Medicine
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026