Thymoquinone-Loaded pHEMA Cryogel Membranes for Superior Control of Staphylococcus aureus Infections
Yildirim M. Cimentepe M. Dogan K. Necip A. Amangeldinova M. Dellal Ö. Poyraz S.
November 2024Pleiades Publishing
Russian Journal of General Chemistry
2024#94Issue 113079 - 3089 pp.
Abstract: This study aims to prepare poly(2-hydroxyethyl methacrylate (pHEMA)-based cryogel membranes loaded with different doses of TQ and to investigate their in-silico properties, effects on HDFa fibroblast cells, and impact on Staphylococcus aureus bacteria. The highest binding affinity of TQ against various Staphylococcus aureus proteins (PDB ID: 3U2D, PDB ID: 2W9S, PDB ID: 4H8E, PDB ID: 3VSL, PDB ID: 6U3Y, and PDB ID: 1JIJ) was found to be –7.520 kcal/mol for 4H8E, while the lowest binding affinity was –4.426 kcal/mol for 3VSL. The prepared membranes exhibited no cytotoxic effects on HDFa cells while demonstrating strong antibacterial activity against Staphylococcus aureus.
antibacterial , membranes , molecular modelling , nanostructures , pHEMA , thymoquinone
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Faculty of Pharmacy, Department of Biochemistry, Harran University, Sanliurfa, 63300, Turkey
Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Harran University, Sanliurfa, 63300, Turkey
Advanced Technology Research and Application Center, Harran University, Sanliurfa, 63300, Turkey
Department of Pharmacy Services, Vocational School of Health Services, Harran University, Sanliurfa, 63300, Turkey
al-Farabi Kazakh National University, Faculty of Biology and Biotechnology, Almaty, 050040, Kazakhstan
Department of Microbiology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, 63300, Turkey
Independent Researcher, Nevşehir, 50040, Turkey
Faculty of Pharmacy
Faculty of Pharmacy
Advanced Technology Research and Application Center
Department of Pharmacy Services
al-Farabi Kazakh National University
Department of Microbiology
Independent Researcher
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