Tea Tree Oil-Loaded Chitosan Hydrogels for Enhanced Wound Healing and Antimicrobial Activity
Yildirim M. Dogan K. Yiğin A. Cimentepe M. Necip A. Amangeldinova M. Cimentepe O.O.
8 August 2025John Wiley and Sons Inc
ChemistrySelect
2025#10Issue 30
Chitosan hydrogels are cost-effective, biocompatible, and exhibit antibacterial properties, making them ideal carrier systems for plant-based natural oils. Tea tree oil, known for its antioxidant and antibacterial activities, is derived from Melaleuca alternifolia L. The aim of this study is to perform a molecular docking analysis of tea tree oil, successfully incorporate it into chitosan hydrogels, characterize the hydrogels, evaluate their effects against Staphylococcus aureus and Escherichia coli in vitro, and assess their impact on wound healing in an in vivo wound model. Tea tree oil-loaded chitosan hydrogels demonstrated dose-dependent antibacterial activity against Staphylococcus aureus and Escherichia coli. Furthermore, these hydrogels significantly accelerated wound healing. Molecular docking analysis revealed that all major compounds in tea tree oil, except for Myrcene, exhibited higher binding affinity to 1JIJ and 6KZX proteins compared to gentamicin.
Anti-bacterial activity , Chitosan hydrogel , Molecular docking , Tea tree oil , Wound healing
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Department of Biochemistry, Faculty of Pharmacy, Harran University, Sanliurfa, Turkey
Advanced Technology Research and Application Center, Harran University, Sanliurfa, Turkey
Department of Genetics, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkey
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Harran University, Sanliurfa, Turkey
Department of Pharmacy Services, Vocational School of Health Services, Harran University, Sanliurfa, Turkey
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Pharmacology, Faculty of Pharmacy, Harran University, Sanliurfa, Turkey
Department of Biochemistry
Advanced Technology Research and Application Center
Department of Genetics
Department of Pharmaceutical Microbiology
Department of Pharmacy Services
Faculty of Biology and Biotechnology
Department of Pharmacology
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