Uncovering the link between inflammatory rheumatic diseases and male reproductive health: a perspective on male infertility and sexual dysfunction
Yessirkepov M. Kocyigit B.F. Zhakipbekov K. Adilbekov E. Sultanbekov K. Akaltun M.S.
September 2024Springer Science and Business Media Deutschland GmbH
Rheumatology International
2024#44Issue 91621 - 1636 pp.
Inflammatory rheumatic diseases (IRDs) refer to a range of persistent disorders that have a major influence on several physiological systems. Although there is much evidence connecting IRDs to sexual dysfunction and fertility problems, research specifically focusing on male infertility in relation to these diseases is sparse. This review addresses the complicated connection between IRDs and male infertility, emphasising the physiological, psychological, and pharmacological aspects that influence reproductive health outcomes in men with rheumatic conditions. We explore the effects of IRDs and their treatments on many facets of male reproductive well-being, encompassing sexual functionality, semen characteristics, and hormonal balance. Additionally, we present a comprehensive analysis of the present knowledge on the impact of several categories of anti-rheumatic drugs on male reproductive function. Although there is an increasing awareness of the need of addressing reproductive concerns in individuals IRDs, there is a noticeable lack of research especially dedicated to male infertility. Moving forward, more comprehensive research is needed to determine the prevalence, risk factors, and mechanisms driving reproductive difficulties in males with IRDs. We can better assist the reproductive health requirements of male IRD patients by expanding our understanding of male infertility in the setting of rheumatic disorders and implementing holistic methods to care.
Inflammation , Male infertility , Male sterility , Rheumatic diseases , Rheumatism
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Department of Biology and Biochemistry, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Department of Physical Medicine and Rehabilitation, University of Health Sciences, Adana City Research and Training Hospital, Türkiye, Adana, Turkey
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Central City Clinical Hospital, Almaty, Kazakhstan
Department Social Health Insurance and Public Health, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Faculty of Medicine, Department of Physical Medicine and Rehabilitaton, Gaziantep University, Türkiye, Gaziantep, Turkey
Department of Biology and Biochemistry
Department of Physical Medicine and Rehabilitation
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy
Central City Clinical Hospital
Department Social Health Insurance and Public Health
Faculty of Medicine
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