Biomarkers of immunothrombosis and polymorphisms of IL2, IL6, and IL10 genes as predictors of the severity of COVID-19 in a Kazakh population
Yessenbayeva A. Apsalikov B. Massabayeva M. Kazymov M. Shakhanova A. Mussazhanova Z. Kadyrova I. Aukenov N. Shaimardanov N.
June 2023Public Library of Science
PLoS ONE
2023#18Issue 6 JUNE
Objectives To study the role of biological markers of immunothrombosis and polymorphisms of cytokine genes IL2, IL6, IL10 and their influence on the severity of COVID-19 in a Kazakh population. Methods A total of 301 patients of Kazakh nationality with a confirmed diagnosis of COVID-19 participated in the retrospective study, including 142 patients with severe and 159 with a mild course. Single nucleotide polymorphisms IL2R rs1801274, IL6 rs2069840, and IL10 rs1800872 were genotyped by real-time PCR. Activated partial thromboplastin time, normalized ratio, prothrombin index, prothrombin time, fibrinogen prothrombin time, fibrinogen, Ddimer, and C-reactive protein analysis were also conducted. Results The average age of patients with severe COVID-19 is higher than of patients with mild COVID-19 (p = 0.03). The findings showed that fibrinogen, D-dimer, and C-reactive protein were significantly greater in the group of patients with severe COVID-19 (p = 0.0001). A very strong correlation between the severity of COVID-19 with the D-dimer and C-reactive protein (p = 0.9) (p = 0.02) was found. Conclusion The results of our study confirm that D-dimer, fibrinogen, and CRP are biomarkers of inflammation and hypercoagulation that serve as predictors of immunothrombosis affecting the severity of COVID-19. D-dimer is also associated with IL10 rs1800872 gene polymorphism in the Kazakh population with severe COVID-19.
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Medical University Semey, Semey, Kazakhstan
Department of Tumor and Diagnostic Pathology, Nagasaki University, Nagasaki, Japan
High Medical School, Faculty of Medicine and Health Care, Al Farabi Kazakh National University, Almaty, Kazakhstan
Shared Resource Laboratory of Karaganda Medical University, Karaganda, Kazakhstan
Department of Health and Human Resources, Ministry of Health of the Republic of Kazakhstan, Astana, Kazakhstan
Medical University Semey
Department of Tumor and Diagnostic Pathology
High Medical School
Shared Resource Laboratory of Karaganda Medical University
Department of Health and Human Resources
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