Hemostasis Gene Polymorphism in Retinal Vascular occlusion: A Systematic Review
Yersariyeva Z. Suleeva B. Turdalieva B. Tussipbayev Y.
January 2025Georgian Association of Business Press
Georgian Medical News
2025#364-365Issue 7-818 - 28 pp.
Purpose: Retinal vascular occlusion (RVO), a common reason for vision loss, is divided into central and branch RVO. Although age, hypertension, and diabetes are established risk factors, genetic variations in hemostasis-related genes like Prothrombin G20210A, Factor V Leiden, and MTHFR may also contribute. Yet, there is conflicting evidence connecting these genetic variations to RVO. The objective of this research is to conduct a thorough evaluation and examination of the connection between variations in hemostasis genes, such as MTHFR C677T and A1298C, and retinal vessel occlusion. Methods: A comprehensive review and meta-analysis were performed adhering to PRISMA standards. Databases (PubMed, Google Scholar, Ovid, Wiley) were queried for Englishlanguage studies (2018–2024) using keywords: “retinal vessel occlusion,” “hemostasis genes,” “thrombophilia,” “Prothrombin G20210A,” “Factor V Leiden,” and “MTHFR polymorphism.” This study included ten studies (n=2281 patients) that were published from 2019 to 2024. The level of heterogeneity for each polymorphism was determined utilizing a random-effects model, while quality of assessment was done using Cochrane risk of bias tool. Results: There was no notable link observed between the MTHFR C677T polymorphism and RVO (P=0.90, OR=0.77, 95% CI=0.55–1.18, I2=0%). Equivalent findings were recorded for A1298C (P=0.84, OR=0.93, 95% CI=0.48–1.81, I2=27%) and MMP2-1306C/T (P=0.10, OR=0.70, 95% CI=0.41–1.20, I2=68%). Though there is some evidence linking polymorphisms in hemostasis genes like MTHFR C677T, A1298C, and others to hypercoagulable conditions, their connection to retinal vessel occlusion is still uncertain. Conclusion: Some individual studies suggested a role for MTHFR polymorphisms in RVO, our meta-analysis found no significant association between these genetic variants and RVO risk. This underscores the need for further research to clarify the interplay of genetic and environmental factors in RVO pathogenesis.
hemostasis gene polymorphism , hyperhomocysteinemia , Retinal vein occlusion , thrombophilic mutations
Text of the article Перейти на текст статьи
Kazakhstan`s Medical University “Graduate School of Public Health”, Almaty, Kazakhstan
LLP “Regional Diagnostic Center - Ophthalmological Center”, Almaty, Kazakhstan
Kazakh Scientific Center of Dermatology and Infectious Diseases of the Ministry of Health of the Republic of Kazakhstan, Almaty, Kazakhstan
Central City Clinical Hospital, Almaty, Kazakhstan
Kazakhstan`s Medical University “Graduate School of Public Health”
LLP “Regional Diagnostic Center - Ophthalmological Center”
Kazakh Scientific Center of Dermatology and Infectious Diseases of the Ministry of Health of the Republic of Kazakhstan
Central City Clinical Hospital
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026