Extraction, Purification and Characterisation of four new alkaloids from the water plant Pistia stratiotes: POM Analyses and Identification of Potential Pharmacophore Sites
Yernazarova G.I. Ramazanova A.A. Turasheva S.K. Almalki F.A. Hadda T.B. Orazova S.B. Madenova A.K. Admanova G.B. Korulkin D.Y. Sabdenalieva G.M. Naimi S. Bukharbayeva Z. Amangeldinova M.E.
July 2023Research Journal of Pharmacy and Technology
Research Journal of Pharmacy and Technology
2023#16Issue 73410 - 3416 pp.
Currently, during the period of intensive development of scientific production, it is important to obtain phytopreparations from sources of raw materials of plant origin. The biological diversity of plants is amazing. The study of the composition of aquatic plants rich in active substances of biotechnological significance is currently an urgent problem. Biologically active substances are involved in various regenerative reactions and metabolic processes in the organism, being part of enzymes. Alkaloids are important nitrogenous compounds found in the plant and are widely used in medicine. The aim of the present study was to identify alkaloid compounds from the composition of the aquatic plant Pistia stratiotes, grown in a model experiment in laboratory conditions by highly effective liquid chromatography and determine the molecular structure by nuclear magnetic resonance. In addition, based on the molecular structure of alkaloid compounds found in the aquatic plant Pistia stratiotes, a study of the properties of pharmaceutical activity was conducted on the pharmaceutical site POM (Petra/Osiris/Molinspiration). According to the results of the study, 4 types of identified alkaloids were identified by the IR,1H,13C-NMR method. They: 1-Aza-10-methoxy-4-methyl-2-oxo-1,2-dihydroanthracene-9-O-b-D-glucopyranoside, 4,6-dimethoxy-8-prenyloxyfuroquinoline, 4,7-dimethoxy-6-(3 ’-methyl-3 ’-methoxy-2 -oxy) butyl-oxifuroquinoline, 4,7-dimethoxy-6-(3 ’-methyl-2 ’-oxy-3 -chlorine)butyloxifuroquinoline. As a result of the analysis of the identified POM alkaloids (Petra/Osiris/Molinspiration), predictions of antitumor activity were made. The presence of a (NHd+---Od-) moiety indicates a potential antitumor pharmacophore site. The challenge is to verify our hypothesis experimentally and to confront virtual POM data and real anticancer screening.
Alkaloids , Identification of pharmacophore sites , Liquid chromatography , Pistia stratiotes , POM (Petra/Osiris/Molinspiration) analyses
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Al-Faraby Kazakh National University, Almaty, 050040, Kazakhstan
Kazakh National Womens Teacher Training University, Almaty, 050000, Kazakhstan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm AlQura University, Makkah, 21955, Saudi Arabia
ACE Laboratory, FSO, Mohammed Premier University, Oujda, 60000, Morocco
Kazakh National Agrarian Research University, Almaty, 050010, Kazakhstan
K. Zhybanov Aktobe Regional University, Aktobe, 030000, Kazakhstan
Abai Kazakh National Pedagogical University, Almaty, 050010, Kazakhstan
Department of Biological Sciences, Sanofi-Aventis, Vitry, France
Al-Faraby Kazakh National University
Kazakh National Womens Teacher Training University
Department of Pharmaceutical Chemistry
ACE Laboratory
Kazakh National Agrarian Research University
K. Zhybanov Aktobe Regional University
Abai Kazakh National Pedagogical University
Department of Biological Sciences
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