Saturation and standard biopsy of the prostate: comparative analysis of efficiency and safety at various prostate-specific antigen levels (Clinical research)

Yermek E.N.
1 April 2025 Kaz Med Print LLP

Reproductive Medicine (Central Asia)
2025 #2025 Issue 1 122 - 126 pp.

Relevance: Prostate cancer (PCa) remains a leading cause of morbidity and mortality among men. Traditional diagnostic methods face limitations in detecting clinically significant cancer. Saturation biopsy, which involves collecting tissue from more points, has improved diagnostic accuracy, especially in patients with elevated prostate-specific antigen (PSA) levels. This study compares saturation and standard biopsies regarding PSA levels, cancer detection rates, and complication frequency. Prostate biopsy is the primary diagnostic method for PCa. Saturation biopsy, involving more than 21 cores, is recommended for patients with previously negative biopsy results but persistent suspicion of PCa. We analyzed our experience to evaluate the applicability of saturation biopsy as a primary diagnostic method for patients suspected of having PCa. The study aimed to assess the efficiency of saturation biopsy compared to the traditional biopsy technique in patients at various prostate-specific antigen levels. Materials and Methods: This study included 1807 patients divided into two groups. Group 1 (n=93) underwent saturation biopsy with tissue sampling from 21-28 cores for PSA levels between 4 and 10 ng/mL. Group 2 (n=1714) underwent a standard biopsy with 12 cores for PSA levels between 3.9 and 19.7 ng/mL. Outcomes were evaluated using the Clavien-Dindo classification. Results: PCa detection rates were 50.5% in Group 1 and 46.4% in Group 2. Among patients with PSA levels below 10 ng/mL, saturation biopsy demonstrated superior detection rates (50.5% vs. 42.4%). The complication rates in both groups approximated 5%, with no significant differences observed. Conclusion: Saturation biopsy is an effective diagnostic method for patients with PSA levels between 4 and 10 ng/mL. It improves cancer detection without increasing the risk of complications. This method is recommended as a primary diagnostic tool for selected patient categories.

complications , diagnosis , Prostate cancer (PCa) , PSA levels , saturation biopsy

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Academy of Public Administration under the President of the Republic of Kazakhstan, Astana, Kazakhstan
Kyrgyz State Medical Academy named after A.K. Akhunbaev, Bishkek, Kyrgyzstan

Academy of Public Administration under the President of the Republic of Kazakhstan
Kyrgyz State Medical Academy named after A.K. Akhunbaev

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