Encapsulation of Insulin in Biodegradable Polymers
Yerlan G.Ye. Tyussyupova B.B. Tazhibayeva S.M. Musabekov K.B. Balabushevich N.G. Kokanbayev A.K.
12 December 2022al-Farabi Kazakh State National University
Eurasian Chemico-Technological Journal
2022#24Issue 4351 - 361 pp.
Encapsulation of insulin into alginate particles was carried out by the method of ionotropic gelation. To protect against the acidic, alkaline environment of the gastrointestinal tract, alginate particles were coated with gelatin. The optimal concentration of the solution of the crosslinking agent ‒ CaCl2 was determined during the optimization of the particle preparation method. The mechanism of interaction between alginate and gelatin was investigated using FTIR spectroscopy, FTIR spectra data confirm the formation of a polyelectrolyte complex between alginate an-d gelatin. The roughness and morphology of samples were determined by atomic force microscopy. The swelling of particles under simulated pH conditions of various parts of the human gastrointestinal tract was studied. The release of insulin from the particles was evaluated using UV spectroscopy, at pH 6.86; 9.18 the release of insulin reached 50%; 83% relatively.
Crosslinking agent , Diabetes mellitus , Encapsulation , Insulin , Ionotropic gelation method
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al-Farabi Kazakh National University, 71 Al-Farabi ave., Almaty, Kazakhstan
Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow, Russian Federation
al-Farabi Kazakh National University
Lomonosov Moscow State University
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