The Effect of Copper Oxide Nanoparticles on Hepatic and Renal Toxicity in Domestic Rabbits

Yegeubayeva S. Karimberdievna A.F. Kunakbayev A. Sherzod R. Munojat B. Faxritdinovna S.G. Omonov B. Ugli B.O.K. Makhliyokhon M. Anvarjon K. Sapaev I.B. Azamovna M.M. Makhamadovich K.R.
2024 University of Kashan

Journal of Nanostructures
2024 #14 Issue 1 150 - 155 pp.

The production and use of engineered nanomaterials in various industries, especially the food industry, and its influence in food products have caused concerns in the field of health. The aim of this study is to investigate the toxicity level and evaluate the effects of copper oxide nanoparticles (CuO NPs) on internal tissues. For this purpose, the effect of different doses of copper oxide nanoparticles in the kidney tissue of rabbits was evaluated. In this experimental study, 48 domestic rabbits were randomly divided into 4 groups of 12 cases. One group was considered as the control group, and three groups of rabbits were injected with doses of 5, 15, and 25 mg of oxide nanoparticles in 3 times a day for 15 days. Then, the biochemical factors (Blood Urea Nitrogen), BUN, Uric Acid (UA) and Creatinine (Cr) were measured in the kidney. The kidney tissue was examined in three stages of blood collection (one day, 8 days and 15 days after the treatment). Also, after 15 days, the animals were isolated and the kidney tissue sections were prepared and studied with hematoxylin-eosin staining. The activity of kidney biochemical factors did not show any significant change between the different groups in the blood collection stages, so that in the first blood collection, there was a significant increase in all three treatment groups compared to the control group. The control showed the greatest changes after 15 days (the third blood draw). There was no significant statistical difference in the weight of the rabbits between the different groups. Histological studies showed multiple tissue damage in the treatment groups, including hyperemia, degeneration of hepatocytes, hyperplasia and inflammation. Microscopic results also showed that the most changes in hepatocyte cells, central lobular vein and sinusoidal space and cause tissue damages.

Copper oxide nanoparticles , Kidney performance , Tissue structure , Toxicity

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Almaty Technological University, Almaty, Kazakhstan
Nukus State Pedagogical Institute named after Ajiniyaz, Uzbekistan
Department of Anatomy with Physiology Courses, Kazakh-Russian Medical University, Almaty, Kazakhstan
Department of Technology, University of Geological Sciences, Uzbekistan
University of Geological Sciences, Uzbekistan
Department of Environmental Hygiene, Tashkent Medical Academy, Uzbekistan
Department of Mechanical and Aerospace engineering, Turin Polytechnic University, Tashkent, Uzbekistan
Department of Fruits and Vegetables, Urganch State University, Uzbekistan
Andijan State Institute of Foreign Languages, Uzbekistan
Termez State University, Termez, Uzbekistan
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan
University of Tashkent for Applied Sciences, Uzbekistan
Western Caspian University, Scientific researcher, Baku, Azerbaijan
Faculty of Agriculture, Fergana State University, Uzbekistan

Almaty Technological University
Nukus State Pedagogical Institute named after Ajiniyaz
Department of Anatomy with Physiology Courses
Department of Technology
University of Geological Sciences
Department of Environmental Hygiene
Department of Mechanical and Aerospace engineering
Department of Fruits and Vegetables
Andijan State Institute of Foreign Languages
Termez State University
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers
University of Tashkent for Applied Sciences
Western Caspian University
Faculty of Agriculture

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