Glyoxalase-based toolbox for the enantioselective synthesis of α-hydroxy carboxylic acids
Yedigenov M. Amire N. Abdirassil A. Mulikova T. Begenov A. Kiesilä A. Peshkov A.A. Peshkov V.A. Utepbergenov D.
7 April 2024Royal Society of Chemistry
Organic and Biomolecular Chemistry
2024#22Issue 132539 - 2543 pp.
We report highly enantioselective synthesis of l-α-hydroxy carboxylic acids (l-αHCAs) via enzymatic intramolecular Cannizzaro reaction of (hetero)aryl glyoxals in the presence of glutathione-independent human glyoxalase DJ-1. Combined with the optimized synthesis of d-αHCAs using glyoxalases I and II, this approach offers a general, scalable and operationally simple access to both enantiomers of α-hydroxy acids in moderate to excellent yields with uniformly high enantioselectivity. This journal is
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Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, 53 Kabanbay Batyr Ave, Astana, 010000, Kazakhstan
Department of Chemistry, University of Jyväskylä, Survontie 9 B, FI-40014, Finland
Department of Chemistry
Department of Chemistry
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