The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Yan Y.-Y. Zhou W.-M. Wang Y.-Q. Guo Q.-R. Zhao F.-X. Zhu Z.-Y. Xing Y.-X. Zhang H.-Y. Aljofan M. Jarrahi A.M. Makabel B. Zhang J.-Y.
21 July 2021 Frontiers Media S.A.

Frontiers in Molecular Biosciences
2021 #8

SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections. © Copyright

ACE2 , COVID-19 , extracellular vesicles (EVs) , immunomodulation , mesenchymal stem cell (MSC) , SARS-CoV-2

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School of Medicine, Shanxi Datong University, Datong, China
Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Xinjiang Institute of Materia Medica, Urumqi, China
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

School of Medicine
Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease
Xinjiang Institute of Materia Medica
Department of Biomedical Sciences
School of Medicine

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