Are two beneficial mutations (p.Q249R and 90-bp Indel) within the ovine BMPRIB gene associated with growth traits?

Xu H. Akhmet N. Luo Y. Guo Z. Pan C. Song E. Malmakov N. Akhatayeva Z. Lan X.
2023 Frontiers Media SA

Frontiers in Veterinary Science
2023 #10

Background: The problem of achieving economic efficiency in sheep breeding can be largely solved by increasing sheep productivity. Recently, the BMPRIB gene has been revealed by GWAS as a potential candidate gene for sheep body morphometric traits. Therefore, the present study aimed to investigate whether genetic polymorphisms (p.Q249R SNP and 90-bp deletion) in the BMPRIB gene are associated with sheep growth traits. Methods: PCR-based genotyping was performed on 1,875 sheep, including 1,191 Guiqian semi-fine wool (GQSFW), 560 Luxi Blackhead (LXBH), 55 Lanzhou fat-tailed (LZFT), and 69 Weining (WN) sheep. Genotype–phenotype association was assessed using the independent samples t-test and ANOVA. The significance level was set at α_original < 0.05. The threshold p-value for significance was adjusted after correction for multiple comparisons using the Bonferroni correction. Results: After the Bonferroni correction, it was found that individuals with FecB⁺/FecB⁺ genotypes of the p.Q249R had significantly better growth traits in LXBH ewe lambs, including the body length, chest width, paunch girth, cannon circumference, and hip width (P<0.0005). Meanwhile, associations were observed between 90-bp deletion polymorphism and several growth traits (body length, body height, chest depth, and canon circumference) in GQSFW ewe adults after the Bonferroni correction (P < 0.0002), and individuals with the “DD” genotypes had greater growth traits. Conclusion: Our findings align with the experimental observations from GWAS, which identified the BMPRIB gene as a potential candidate gene for body measurement traits. These findings not only confirm the previous studys results but also expand on them. Therefore, further investigations regarding the impact of BMPRIB polymorphisms on growth traits are necessary in other sheep breeds. Copyright

FecB (BMPRIB) , growth traits , MAS , polymorphism , sheep

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College of Life Science and Engineering, Northwest Minzu University, Gansu, Lanzhou, China
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest AF University, Shaanxi, Yangling, China
Bijie Animal Husbandry and Veterinary Science Research Institute, Guizhou, Bijie, China
Shandong Key Lab of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China
Scientific Research Institute of Sheep Breeding Branch, Kazakh Scientific Research Institute of Animal Husbandry and Fodder Production, Almaty Region, Mynbaev, Kazakhstan

College of Life Science and Engineering
Key Laboratory of Animal Genetics
Bijie Animal Husbandry and Veterinary Science Research Institute
Shandong Key Lab of Animal Disease Control and Breeding
Scientific Research Institute of Sheep Breeding Branch

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