Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
Xie Y. Mu C. Kazybay B. Sun Q. Kutzhanova A. Nazarbek G. Xu N. Nurtay L. Wang Q. Amin A. Li X.
2021Taylor and Francis Ltd.
Drug Delivery
2021#28Issue 12187 - 2197 pp.
Rhizoma polygonati (Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated RP extract combination with kinase inhibitors in anti-cell growth and blockade in pathways targeting kinases. Experimental investigation and network pharmacology analysis were applied to test the potent kinase-mediated signaling. Herbzyme activity was determined by substrate with optical density measurement. Extract of processed RP inhibits cell growth in a much greater manner than alone when applied in combination with inhibitors of mTOR or EGFR. Moreover, processing methods of RP from Mount Tai (RP-Mount Tai) play essential roles in herbzyme activity of phosphatase suggesting the interface is also essential, in addition to the chemical component. The network pharmacology analysis showed the chemical component and target networks involving AKT and mTOR, which is consistent with experimental validation. Finally, EGFR inhibitor could be associated with nano-extract of RP-Mount Tai but not significantly affects the phosphatase herbzyme activity in vitro. Thus the processed extract of RP-Mount Tai may play a dual role in the inhibition of cell proliferation signaling by both chemical component and nanoscale herbzyme of phosphatase activity to inhibit kinases including mTOR/AKT in potent drug delivery of kinase inhibitors.
herbzyme , Huangjing , traditional Chinese medicine
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Department of Biology, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan, Kazakhstan
Sino-German Joint Research Center on Agricultural Biology, State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Shandong Province, Taian, China
Key Laboratory for Applied Technology of Sophisticated Analytical Instrument of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China
Shandong Taishanghuangjing Biotechnology Co. Ltd, Taian, China
Biology Department, UAE University, Al Ain, United Arab Emirates
The College, The University of Chicago, Chicago, IL, United States
Department of Biology
Sino-German Joint Research Center on Agricultural Biology
Key Laboratory for Applied Technology of Sophisticated Analytical Instrument of Shandong Province
Shandong Taishanghuangjing Biotechnology Co. Ltd
Biology Department
The College
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