Microneedle-Enabled Breakthroughs in Nucleic Acid Therapeutics
Wu P. Zhang T. Zhao D. Xie Y. Huang D. Li Z. Huang Y.
23 June 2025John Wiley and Sons Inc
Advanced Healthcare Materials
2025#14Issue 16
Nucleic acid therapy demonstrates great potential in cancer treatment, infectious disease prevention, and vaccine development due to its advantages, such as rapid production, long-lasting effects, and high target specificity. Although nucleic acid therapy is considered ideal for the development of novel therapeutic strategies, its clinical application still faces numerous challenges, including the lack of efficient delivery systems, insufficient drug formulation stability, and the limitations imposed by the skin barrier on drug dosage delivery. Microneedles, as an innovative transdermal drug delivery technology, can penetrate the stratum corneum and directly access the skins microcirculation, enabling the efficient delivery of genes and drugs. This technology offers several advantages, such as ease of operation, minimally invasive and painless application, and high safety. Combining microneedle technology with nucleic acid therapy fully leverages the strengths of both approaches, significantly enhancing therapeutic efficacy and bioavailability while maximizing treatment potential. This review explores the application prospects and advantages of combining microneedle delivery systems with nucleic acid therapy.
DNA vaccine , drug delivery systems , microneedle , nucleic acid therapeutics , RNA vaccine
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School of Life Science, School of Interdisciplinary Science, Aerospace Center Hospital, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical, Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, China
School of Medical Engineering, School of Interdisciplinary Science, Affiliated Zhuhai Peoples Hospital, Beijing Institute of Technology, Zhuhai, 519088, China
Advanced Technology Research Institute, Beijing Institute of Technology, Jinan, 250100, China
Zhengzhou Research Institute, Beijing Institute of Technology, Zhengzhou, 450040, China
Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, 450000, China
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
National Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Integrated Circuits, Peking University, Beijing, 100871, China
AciMicro Medical Technology, Guangzhou, 510700, China
School of Life Science
School of Medical Engineering
Advanced Technology Research Institute
Zhengzhou Research Institute
Department of Radiation Oncology
Department of Biology
National Key Laboratory of Advanced Micro and Nano Manufacture Technology
AciMicro Medical Technology
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