Effects of low-dose atorvastatin on the peripheral blood mononuclear cell secretion of angiogenic factors in type 2 diabetes
Wesołowska A. Winiarska H. Owoc J. Borowska M. Domagała J. Mikołajczak P.Ł. Iskakova S. Dworacki G. Dworacka M.
December 2021MDPI
Biomolecules
2021#11Issue 12
The aim of this study was to investigate the influence of statins on the secretion of angiogenesis mediators by the peripheral blood mononuclear cells (PBMCs) derived from patients suffering from type 2 diabetes. The study group comprised 30 participants and included: 10 statintreated patients with diabetes, 10 statin-free diabetic subjects, and 10 statin-free non-diabetic individuals. PBMCs isolated from the blood were cultured in vitro in standard conditions and in an environment mimicking hyperglycemia. Culture supernatants were evaluated for VEGF, MCP-1, Il-10, and Il-12 by flow cytometry using commercial BD™. Cytometric Bead Array tests. The secretion of VEGF, MCP-1 and Il-12 by PBMCs, cultured both in standard and hyperglycemic conditions, was significantly lower in the statin-treated patients with type 2 diabetes in comparison with the statin-free diabetic patients. Conversely, the secretion of Il-10 was higher in the statin-treated than in the statin-free diabetic patients. VEGF, MCP-1 and Il-12 levels in PBMCs supernatants from the glucose-containing medium were higher than those from the standard medium in each of the diabetic groups. The results of the study suggest that statins in low doses exhibit an antiangiogenic activity, reducing the secretion of potent proangiogenic factors, such as VEGF and MCP-1, and increasing the secretion of antiangiogenic Il-10 by PBMCs, also under hyperglycemic conditions characteristic for type 2 diabetes.
Angiogenic factors , Diabetes , Hyperglycemia , Peripheral blood mononuclear cells , Statins
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Department of Pharmacology, Poznan University of Medical Sciences, Poznan, 60-805, Poland
Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, 60-805, Poland
Department of Pharmacology, Asfendiyarov Kazakh National Medical University, Tole Bi Str. 94, Almaty, 050000, Kazakhstan
Department of Pharmacology
Department of Clinical Immunology
Department of Pharmacology
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