Helicobacter pylori infection in children with phenylketonuria does not depend on metabolic control and is not more frequent than in healthy subjects—a cross-sectional study
Walkowiak M. Kałużny Ł. Mozrzymas R. Jamka M. Mikołuć B. Jagłowska J. Starostecka E. Nurgaliyeva R. Walkowiak J. Lisowska A.
August 2021MDPI
Children
2021#8Issue 8
In a small preliminary study, phenylketonuria and poor metabolic control were suggested as risk factors for Helicobacter pylori infection in children as detected with an antigen stool test. We aimed to determine Helicobacter pylori prevalence in an adequately sized group of individuals with phenylketonuria and healthy subjects using the standard gold test (urea breath test). Further, we correlated Helicobacter pylori infection with metabolic control. The study comprised 103 individuals with phenylketonuria and 103 healthy subjects on whom a13C urea breath test was performed. Blood phenylalanine levels in the preceding year were analysed. The infection rate did not differ between individuals with phenylketonuria and healthy subjects (10.7% vs 15.5%; p = 0.41). The frequency of testing and phenylalanine concentrations of Helicobacter pylori-positive and Helicobacter pylori-negative patients with phenylketonuria did not differ (p = 0.92 and p = 0.54, respectively). No associations were detected for body mass index or metabolic control. Forward stepwise regression models revealed that age (p = 0.0009–0.0016) was the only independent correlate of Helicobacter pylori infection with a relatively low fraction of the variability of the condition being explained (adjR2 = 0.0721–0.0754; model p = 0.020–0.023). In conclusion, Helicobacter pylori infection in phenylketonuria is not more frequent than in the general population. Moreover, it does not depend on metabolic control.
Anthropometry , Inborn errors of metabolism , Paediatrics , Phenylalanine
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Department of Reproduction, Poznan University of Medical Sciences, Polna Str. 33, Poznan, 60-535, Poland
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, Poznan, 60-572, Poland
Research and Development Center, Regional Specialist Hospital, Kamieńskiego Str. 73a, Wrocław, 51-124, Poland
Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, Waszyngtona Str. 17, Bialystok, 15-274, Poland
Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Dębinki Str. 7, Gdansk, 80-211, Poland
The Regional Center of Rare Diseases, Polish Mother’s Memorial Hospital Research Institute, Rzgowska Str. 281/289, Łodź, 93-338, Poland
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Maresyev Str. 68, Aktobe, 030019, Kazakhstan
Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Szpitalna Str. 27/33, Poznan, 60-572, Poland
Department of Reproduction
Department of Pediatric Gastroenterology and Metabolic Diseases
Research and Development Center
Department of Pediatrics
Department of Pediatrics
The Regional Center of Rare Diseases
Department of Normal Physiology
Department of Clinical Auxology and Pediatric Nursing
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