DETERMINATION OF STANDARDIZATION PARAMETERS OF OXYCOCCUS MACROCARPUS (AIT.) PURSH AND OXYCOCCUS PALUSTRIS PERS. LEAVES

Vlasova I. Gontova T. Grytsyk L. Zhumashova G. Sayakova G. Boshkayeva A. Shanaida M. Kоshovyi О.
2022 Technology Center

ScienceRise: Pharmaceutical Science
2022 #2022 Issue 3 48 - 57 pp.

The aim. Extracts of cranberry large leaves have prospects when used to correct insulin-resistant conditions. There-fore, to create new drugs based on cranberry leaves, you need to develop instructions for cultivating the plant, harvesting raw materials and methods of quality control. Therefore, the aim of the research was to determine the parameters of standardization of large cranberry leaves (Oxycoccus macrocarpus (Ait.) Pursh) and swamp cranberries (Oxycoccus palustris Pers.). Materials and methods. Macro-and microscopic studies of raw materials were performed according to the method of SPhU 2.8.23 “Microscopic examination of medicinal plant raw materials”. Macroscopic examinations were performed using a magnifying glass and MBS-9 binocular microscope. Identification of basic substances was performed by TLC, testing and quantification of flavonoids according to SPhU methods. Results. The morphological and anatomical features of the leaves of common cranberry and large cranberry were determined. The general features of the structure of stems and leaves species and different differences for each species are were revealed. TLC identification of the main BAS of raw materials was developed and standardization parameters were determined. Conclusions. The parameters of cranberry leaf standardization are determined by the following indicators: mac-ro-and microscopic features, TLC identification of the main BAS raw materials (hyperoside, rutin and caffeic acid), impurities (not more than 2 %), brown stems not more than 5 %, weight loss during drying (not more than 10 %), total ash (not more than 7 %) and not less than 1 % of flavonoids, in terms of hyperoside.

common cranberry , large cranberry , leaves , morphological and anatomical features , standardization

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Department of Pharmacognosy, National University of Pharmacy, Pushkinska str., 53, Kharkiv, 61002, Ukraine
Department of Chemistry, Pharmaceutical Analysis and Postgraduate Education, Ivano-Frankivsk National Medical University, Ukraine
Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, Asfendiyarov Kazakh National Medical University, Tole-bi str., 94, Almaty, 050000, Kazakhstan
Department of Pharmacognosy and Medical Botany, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Voli ave., 1, Ternopil, 46001, Ukraine

Department of Pharmacognosy
Department of Chemistry
Department of Pharmaceutical and Toxicological Chemistry
Department of Pharmacognosy and Medical Botany

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