Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments
Vinogradova E. Jarmukhanov Z. Nurgaziyev M. Kossumov A. Nurgozhina A. Mukhanbetzhanov N. Sergazy S. Chulenabyeva L. Issilbayeva A. Askarova S. Kaiyrlykyzy A. Rakhimova S. Kozhamkulov U. Kairov U. Khassenbekova Z. Tarzhanova D. Akilzhanova A. Lee J.H. Terwilliger J. Sailybayeva A. Bekbossynova M. Zhumadilov Z. Kozhakhmetov S. Kushugulova A.
30 January 2025Elsevier Ltd
Heliyon
2025#11Issue 2
Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome composition, characterized by an increase in the relative abundance of Enterococcus and correlated with vitamin D deficiency and, as consequence, with memory impairments. A key mechanism identified in the study was the differential utilization of short-chain fatty acids (SCFAs) produced by gut bacteria as substrates for synthesizing vitamin D3 precursor in the skin. This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.
Butyrate producers , Cognitive impairments , Enterococcus dysbiosis , Gut microbiome , Memory performance , Metabolites , Metagenomics , Short-chain fatty acids (SCFAs) , Vitamin D deficiency , Vitamin D receptor (VDR)
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Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
Department of General Pharmacology, Astana Medical University, Astana, Kazakhstan
Sergievsky Center, Taub Institute, Department of Neurology and Epidemiology, Columbia University, New York, NY, United States
Department of Psychiatry and Genetics & Development, Sergievsky Center, Columbia University, New York, NY, United States
Division of Public Health Genomics, National Institute for Ealth and Welfare, Helsinki, Finland
National Research Cardiac Surgery Center, Astana, Kazakhstan
School of Medicine, Nazarbayev University, Astana, Kazakhstan
Center for Life Sciences
Department of General Pharmacology
Sergievsky Center
Department of Psychiatry and Genetics & Development
Division of Public Health Genomics
National Research Cardiac Surgery Center
School of Medicine
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