Drug Repurposing of Generic Drugs: Challenges and the Potential Role for Government

van der Pol K.H. Aljofan M. Blin O. Cornel J.H. Rongen G.A. Woestelandt A.-G. Spedding M.
November 2023 Adis

Applied Health Economics and Health Policy
2023 #21 Issue 6 831 - 840 pp.

Drug repurposing is the process of identifying a new use for an existing drug or active substance in an indication outside the scope of the original indication. Drug repurposing has important advantages including reduced development time and costs, and potentially large societal healthcare cost savings. However, current generic drug repurposing research faces a number of challenges in obtaining research funds. Furthermore, regardless of the success of a repurposing trial, commercial parties often lack interest in pursuing marketing authorisation for financial reasons, and academic researchers lack the knowledge, time and funding. Therefore, the new indication of a repurposed drug often does not make it ‘on label’. We propose a large increase in public funding for generic drug repurposing research, including funds for the marketing authorisation process when a trial is successful, and a reduction in the regulatory burden of the marketing authorisation process for repurposed generic drugs.

Text of the article Перейти на текст статьи

Department of Internal Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands
Department of Biomedical Science, Nazarbayev University School of Medicine, Nur-Sultan, Kazakhstan
National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan
Institut de Neurosciences des Systèmes, Aix Marseille Université, Inserm UMR 1106, Marseille, France
Department of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands
Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands
Spedding Research Solutions SAS, Le Vesinet, 78110, France

Department of Internal Medicine
Department of Biomedical Science
National Laboratory Astana
Institut de Neurosciences des Systèmes
Department of Cardiology
Department of Cardiology
Spedding Research Solutions SAS

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026