Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Vallejo-Vaz A.J. Stevens C.A.T. Lyons A.R.M. Dharmayat K.I. Freiberger T. Hovingh G.K. Mata P. Raal F.J. Santos R.D. Soran H. Watts G.F. Abifadel M. Aguilar-Salinas C.A. Alhabib K.F. Alkhnifsawi M. Almahmeed W. Alnouri F. Alonso R. Al-Rasadi K. Al-Sarraf A. Al-Sayed N. Araujo F. Ashavaid T.F. Banach M. Béliard S. Benn M. Binder C.J. Bogsrud M.P. Bourbon M. Chlebus K. Corral P. Davletov K. Descamps O.S. Durst R. Ezhov M. Gaita D. Genest J. Groselj U. Harada-Shiba M. Holven K.B. Kayikcioglu M. Khovidhunkit W. Lalic K. Latkovskis G. Laufs U. Liberopoulos E. Lima-Martinez M.M. Lin J. Maher V. Marais A.D. März W. Mirrakhimov E. Miserez A.R. Mitchenko O. Nawawi H. Nordestgaard B.G. Panayiotou A.G. Paragh G. Petrulioniene Z. Pojskic B. Postadzhiyan A. Raslova K. Reda A. Reiner Ž. Sadiq F. Sadoh W.E. Schunkert H. Shek A.B. Stoll M. Stroes E. Su T.-C. Subramaniam T. Susekov A.V. Tilney M. Tomlinson B. Truong T.H. Tselepis A.D. Tybjærg-Hansen A. Vázquez Cárdenas A. Viigimaa M. Wang L. 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6 November 2021 Elsevier B.V.

The Lancet
2021 #398 Issue 10312 1713 - 1725 pp.

Background: The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally. Methods: Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Data were assessed overall and by WHO regions, sex, and index versus non-index cases. Findings: Of the 61 612 individuals in the registry, 42 167 adults (21 999 [53·6%] women) from 56 countries were included in the study. Of these, 31 798 (75·4%) were diagnosed with the Dutch Lipid Clinic Network criteria, and 35 490 (84·2%) were from the WHO region of Europe. Median age of participants at entry in the registry was 46·2 years (IQR 34·3-58·0); median age at diagnosis of familial hypercholesterolaemia was 44·4 years (32·5-56·5), with 40·2% of participants younger than 40 years when diagnosed. Prevalence of cardiovascular risk factors increased progressively with age and varied by WHO region. Prevalence of coronary disease was 17·4% (2·1% for stroke and 5·2% for peripheral artery disease), increasing with concentrations of untreated LDL cholesterol, and was about two times lower in women than in men. Among patients receiving lipid-lowering medications, 16 803 (81·1%) were receiving statins and 3691 (21·2%) were on combination therapy, with greater use of more potent lipid-lowering medication in men than in women. Median LDL cholesterol was 5·43 mmol/L (IQR 4·32-6·72) among patients not taking lipid-lowering medications and 4·23 mmol/L (3·20-5·66) among those taking them. Among patients taking lipid-lowering medications, 2·7% had LDL cholesterol lower than 1·8 mmol/L; the use of combination therapy, particularly with three drugs and with proprotein convertase subtilisin-kexin type 9 inhibitors, was associated with a higher proportion and greater odds of having LDL cholesterol lower than 1·8 mmol/L. Compared with index cases, patients who were non-index cases were younger, with lower LDL cholesterol and lower prevalence of cardiovascular risk factors and cardiovascular diseases (all p<0·001). Interpretation: Familial hypercholesterolaemia is diagnosed late. Guideline-recommended LDL cholesterol concentrations are infrequently achieved with single-drug therapy. Cardiovascular risk factors and presence of coronary disease were lower among non-index cases, who were diagnosed earlier. Earlier detection and greater use of combination therapies are required to reduce the global burden of familial hypercholesterolaemia. Funding: Pfizer, Amgen, Merck Sharp & Dohme, Sanofi-Aventis, Daiichi Sankyo, and Regeneron.

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Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom
Centre for Cardiovascular Surgery and Transplantation, Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, Netherlands
Fundación Hipercolesterolemia Familiar, Madrid, Spain
Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Heart Institute (InCor), University of São Paulo, Hospital Israelita Albert Einstein, São Paulo, Brazil
Manchester University NHS Foundation Trust, Manchester, United Kingdom
School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia
Lipid Disorders Clinic, Cardiometabolic Services, Department of Cardiology, Royal Perth Hospital, Perth, WA, Australia
Laboratory of Biochemistry and Molecular Therapeutics, Faculty of Pharmacy, Saint Joseph University, Beirut, Lebanon
Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico
Department of Cardiac Sciences, King Fahad Cardiac Centre, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Faculty of Medicine, University of Al Qadisiyah, Al Diwaniyah, Iraq
Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates
Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan Cardiac Centre, Riyadh, Saudi Arabia
Center for Advanced Metabolic Medicine and Nutrition, Santiago, Chile
Department of Biochemistry, College of Medicine and Health Science, Medical Research Centre, Sultan Qaboos University, Muscat, Oman
Sabah Al Ahmad Cardiac Centre, Kuwait City, Kuwait
Gulf Diabetes and Endocrine Centre, Manama, Bahrain
Portuguese Atherosclerosis Society, Lisbon, Portugal
P D Hinduja Hospital, Medical Research Centre, Mahim, Mumbai, India
Department of Hypertension, Medical University of Lodz, Mothers Memorial Hospital Research Institute, Lodz, Poland
Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland
Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception and Centre de Recherche en Cardiovasculaire et Nutrition (C2VN), UMR 1263, INSERM 1260, INRAE Aix Marseille Université, Marseille, France
Department of Clinical Biochemistry, Rigshospitalet, of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital, Oslo, Norway
Unidade de Investigação e Desenvolvimento, Grupo de Investigação Cardiovascular, Departamento de Promoção da Saúde e Prevenção de Doenças Não Transmissíveis, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal
Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Lisbon, Portugal
1st Department of Cardiology Medical University of Gdańsk, National Centre of Familial Hypercholesterolaemia in Gdańsk, Gdańsk, Poland
FASTA University, School of Medicine, Pharmacology Department, Mar del Plata, Argentina
Research Health Institute, Al Farabi Kazakh National University, Almaty, Kazakhstan
Centre de Recherche Médicale de Jolimont, Centres Hospitaliers Jolimont, Haine-Saint-Paul, Belgium
Cardiology Department, Centre for Treatment and Prevention of Atherosclerosis, Hadassah Hebrew University Medical Centre, Jerusalem, Israel
National Medical Research Centre of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russian Federation
Universitatea de Medicina si Farmacie Victor Babes, Institutul de Boli Cardiovasculare, Fundatia CardioPrevent, Timisoara, Romania
Research Institute, McGill University Health Center, Montreal, QC, Canada
Department of Pediatric Endocrinology, Diabetes and Metabolism, University Medical Centre, University Childrens Hospital Ljubljana, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
National Cerebral and Cardiovascular Centre Research Institute, Osaka, Japan
Department of Cardiology, Ege University Medical School, Izmir, Turkey
Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Faculty of Medicine, University of Belgrade, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia
Research Institute of Cardiology and Regenerative Medicine, Faculty of Medicine, University of Latvia, Pauls Stradins Clinical University Hospital, Riga, Latvia
Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany
Department of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, Greece
Atherothrombosis Research Centre, University of Ioannina, Ioannina, Greece
Universidad de Oriente, Núcleo Bolívar, Ciudad Bolívar, Venezuela
Beijing Anzhen Hospital Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing, China
Advanced Lipid Management and Research Centre (ALMAR), Tallaght University Hospital, Dublin, Ireland
University of Cape Town Health Science Faculty, Cape Town, South Africa
DACH Society for the Prevention of Heart and Circulatory Diseases, Hamburg, Germany
Department of Internal Medicine V, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Klinisches Institut für Medizinische und Chemische Labordiagnostik, Medizinische Universität Graz, Graz, Austria
Synlab Akademie, Synlab Holding Deutschland, Mannheim, Germany
Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
Diagene Research Institute, Swiss Society for Familial Forms of Hypercholesterolemia (SSFH), Reinach, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland
Dyslipidaemia Department, Institute of Cardiology, National Academy of Medical Sciences, Kiev, Ukraine
Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Faculty of Medicine, Universiti Teknologi MARA (UiTM), Selangor, Sungai Buloh, Malaysia
Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus
Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Vilnius University Faculty of Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania
Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina
Medical University of Sofia, Sofia, Bulgaria
Coordination Centre for Familial Hyperlipidemias, Slovak Medical University in Bratislava, Bratislava, Slovakia
Cardiology Department, Faculty of Medicine, Menoufia University, Al Minufiyah, Egypt
Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
Directorate of Research, Shifa Tameer-e-Millat University, Islamabad, Pakistan
Department of Child Health, University of Benin Teaching Hospital, Benin City, Nigeria
Clinic for Heart and Circulatory Diseases, German Heart Centre Munich, Technical University Munich, Munich, Germany
German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
Coronary Heart Disease and Atherosclerosis Department, Republican Specialized Centre of Cardiology, Ministry of Health of Republic Uzbekistan, Tashkent, Uzbekistan
GENYCO Program, Comisión Nacional de Salud Cardiovascular, Montevideo, Uruguay
Departments of Internal Medicine and Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan
Admiralty Medical Centre and Khoo Teck Puat Hospital, Yishun Health, Singapore
Academy for Postgraduate Medical Education, Faculty of Clinical Pharmacology and Therapeutics, Ministry of Health, Moscow, Russian Federation
Lipid Clinic, Mater Dei Hospital, Msida, Malta
Department of Medicine, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
Faculty of Medicine, Macau University of Science and Technology, Macao
Vietnam National Heart Institute, Bach Mai Hospital, Department of Cardiology, Hanoi Medical University, Hanoi, Viet Nam
Facultad de Medicina, Universidad Autónoma de Guadalajara, Zapopan, Mexico
North Estonia Medical Centre, Tallinn University of Technology, Tallinn, Estonia
Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
Rinku General Medical Centre, Osaka, Japan
Department of Cardiology, Hacettepe University, Ankara, Turkey
Centre of Epidemiology and Preventive Pharmacology, Laboratory of Lipoproteins, Immunity and Atherosclerosis, Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy
Dept. of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
Heart Institute InCor, University of Sao Paulo, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
McGill University, Montreal, Canada
Dept. of Internal Medicine, University Hospital Centre Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia
Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic
Medical Faculty, Masaryk University, Brno, Czech Republic
Dept. of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Dept. of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Cardiology Dept., Faculty of medicine, Menoufia University, Menoufia, Egypt
Sorbonne University, Pitié Salpêtrière Hospital APHP, Paris, France
Dept. of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, Greece
Dept. of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Dept of vascular medicine, Academic Medical Centre, Amsterdam, Netherlands
Dept. of Child Health, University of Benin Teaching Hospital, Edo State, Benin City, Nigeria
National Advisory Unit on FH, Oslo University Hospital, Oslo, Norway
Medical Research Center, Sultan Qaboos University, Muscat, Oman
Dept. of Biochemistry, College of Medicine & Health Science, Sultan Qaboos University, Muscat, Oman
Shifa Tameer-e-Millat University, Islamabad, Pakistan
Cardiovascular Prevention Unit, Adult Cardiology Dept., Prince Sultan Cardiac Centre, Riyadh, Saudi Arabia
Dept. of Pediatric Endocrinology, Diabetes and Metabolism, UMC - University Childrens Hospital Ljubljana, Ljubljana, Slovenia
Dept. of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Dept. of Cardiology, Ege University Medical School, Izmir, Turkey
Dyslipidaemia Dept., Institute of cardiology AMS, Kiev, Ukraine
Manchester University NHS Foundation Trust, Manchester, United Kingdom
Coronary Heart Disease and Atherosclerosis Dept., Republican Specialized Centre of Cardiology RSCC, Ministry of Health of Republic Uzbekistan, Tashkent, Uzbekistan
Lab. of Lipids and Atherosclerosis, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia
Dept. of Internal Medicine I, Medical University of Innsbruck, Austria
Institute of Genetic Epidemiology, Medical University of Innsbruck, Austria
Austrian Atherosclerosis Society, Austria
Division of Endocrinology & Metabolism, Dept. of Medicine III, Medical University of Vienna, Austria
Dept. of Pediatrics & Adolescent Medicine, Medical University of Vienna, Austria
Division of Cardiology, Dept. of Internal Medicine II, Medical University of Vienna, Austria
Division of Endocrinology and Diabetology, University of Graz, Austria
Austrian Academic Institute for Nutritional Medicine, Vienna, Austria
Dept. of Endocrinology and Nephrologie, Klinik Hietzing, Vienna, Austria
Dept. of Cardiology, Klinik Ottakring, Vienna, Austria
Dept. of Diabetology, Endocrinology & Nephrology, Klinik Landstrasse, Vienna, Austria
Dept. of Endocrinology, Rheumatology & Acute Geriatrics, Klinik Ottakring, Vienna, Austria
Dept. of Internal Medicine I, Universitätsklinikum Krems, Austria
Dept. of Pediatrics, Academic Teaching Hospital, Landeskrankenhaus Feldkirch, Austria
Dept. of Pediatrics I, University Clinic Innsbruck, Medical University of Innsbruck, Austria
Vivit Institute, Feldkirch, Austria
Dept. of Laboratory Medicine, Medical University of Vienna, Austria
Centres Hospitaliers Jolimont, Belgium
University Clinical Center Sarajevo, Bosnia and Herzegovina
Dept. of Angiology and Electrophysiology, City Clinic, Sofia, Bulgaria
University Hospital Queen Joanna, Clinic of Cardiology, Sofia, Bulgaria
Dept. of Cardiology, Medical University of Plovdiv, Plovdiv, Bulgaria
Dept. of Cardiology, Pulmonology and Endocrinology, Medical University, Pleven, Bulgaria
Dept. of Cardiology, Medical University, Varna, Bulgaria
Dept. of Cardiology, Saint Anna University Hospital, Sofia, Bulgaria
CHU de Québec-Université Laval, Canada
Université de Montreal, Canada
Ecogene-21, Canada
University of British Columbia, Canada
Western University, Canada
University of Toronto, Canada
Montreal Clinical Research Institute, Canada
Clínica Las Condes, Chile
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Dept. of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Dept. of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Dept. of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Dept. of Cardiology, The First Affiliated Hospital of Gannan Medical College, Ganzhou, China
Dept. of Endocrinology and Metabolism, Japan Friendship Hospital, Beijing, China
Dept. of Emergency, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
Dept. of Cardiology, Tianjin Medical University General Hospital, Tianjin, China
Dept. of Paediatrics, Peking University First Hospital, Beijing, China
Dept. of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Dept. of Cardiology, Beijing Civil Aviation General Hospital, Beijing, China
Dept. of Cardiology, Beijing Zhongguancun Hospital, Beijing, China
Dept. of Emergency, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Dept. of Radiology, Beijing Anzhen Hospital, Capital Medical University, China
Dept. of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, China
Dept. of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, China
Dept. of Laboratory Medicine, First Affiliated Hospital of China Medical University, China
The Chinese University of Hong Kong, Hong Kong
Dept. of Internal Medicine, University Hospital Centre Zagreb, School of Medicine University of Zagreb, Croatia
Hippocrateon Private Hospital, Cyprus
Dept. of Pharmacy, Frederick University, Cyprus
General University Hospital, 1st Medical Faculty, Charles University, Prague, Czech Republic
St. Annes University Hospital, Brno, Czech Republic
Centre of Molecular Biology and Gene Therapy, University Hospital Brno, Brno, Czech Republic
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Thomayer Hospital, 1st Medical Faculty, Charles University, Prague, Czech Republic
University Hospital Kralovske Vinohrady, 3rd Medical Faculty, Prague, Czech Republic
University Hospital Motol, Prague, Czech Republic
Hospital Na Homolce, Prague, Czech Republic
University Hospital, Medical Faculty, Charles University, Hradec Kralove, Czech Republic
University Hospital, Medical Faculty, Charles University, Plzen, Czech Republic
University Hospital, Medical Faculty, Palacky University, Olomouc, Czech Republic
Lipid Outpatient Clinic, Karlovy Vary, Czech Republic
Regional Hospital Ceske Budejovice, Czech Republic
Hospital Pisek, Czech Republic
Outpatient Interkrim Clinics, Usti nad Labem, Czech Republic
Regional Hospital Liberec, Czech Republic
Regional Hospital Trutnov, Czech Republic
Hospital Jablonec nad Nisou, Czech Republic
Regional Hospital Jicin, Czech Republic
Hospital of the Pardubice Region, Czech Republic
Edumed, Nachod, Czech Republic
Regional T. Bata Hospital, Zlin, Czech Republic
Ormiga Medical House, Zlin, Czech Republic
Lipid Outpatient Clinics, Uherske Hradiste, Czech Republic
Hospital Trebic, Czech Republic
Hospital Vyskov, Czech Republic
Outpatient Mephacentrum Clinics, Ostrava, Czech Republic
Ostrava City Hospital, Ostrava, Czech Republic
Hospital Frydek-Mistek, Czech Republic
Hospital Krnov, Czech Republic
Dept. of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Dept. of Clinical Medicine, Faculty of Health and medical Sciences, University of Copenhagen, Denmark
Benha University, Faculty of Medicine, Cardiology Dept., Egypt
Italian Hospital, Cairo, Egypt
Military Medical Academy, Egypt
Port-Foad Cardiac Centre, Egypt
Alexandria University, Faculty of Medicine, Cardiology Dept., Egypt
National Heart Institute, Giza, Egypt
Cairo University, Critical Care Dept., Egypt
Hayat Hospital, Cairo, Egypt
Cairo University, National Cancer Institute, Biostatistics Dept., Egypt
Tallinn University of Technology, Estonia
Tours University, CHRU de Tours, Cardiology Dept., EA4245 T2i, Loire Valley Cardiovascular Collaboration, Tours, F37000, France
APHM, Hôpital de la Conception, Centre de Recherche en Cardiovasculaire et Nutrition C2VN, UMR 1263, INSERM 1260, INRAE, Aix Marseille Université, Marseille, France
AP-HP, Hôpitaux de lEst Parisien, Hôpital Saint-Antoine, Service de Cardiologie, Faculty of Medicine, Sorbonne Université, National Institute of Health and Medical Research, INSERM, UMR_S 938, UPMC, Paris, France
LInstitut du Thorax, Endocrinology Dept., CIC 1413 INSERM, CHU de Nantes, Nantes, France
La Pitié Salpêtrière hospital APHP, France
Sorbonne University, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), UMR_S1166, APHP, Dept. of Biochemistry, Obesity and Dyslipidemia Genetics Unit, Hôpital de la Pitié, Paris, France
Hospices Civils de Lyon, Endocrinology Dept., University of Lyon 1, Bron, France
Dept. of Cardiology, CHU de Dijon-Bourgogne, Dijon, 21000, France
Dept. of Biochemistry and Molecular Biology, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron, France
Internal Medicine Dept., Unit of Endocrinology, CHRU Tours, Tours, F-37044, France
CHU Pontchaillou, Centre de Prévention Cardio-vasculaire, Pôle CPV, Rennes, France
Pôle Thoracique / Cardiaque / Vasculaire, Centre Hospitalo-Universitaire, Reims, France
Lipid Clinic, Point Médical, Dept. of Cardiology, CHU Dijon-Bourgogne, Dijon, France
Dept. of Cardiology, University Hospital of Nice, Nice, France
Toulouse Rangueil University Hospital, Dept. of Cardiology, UMR1027, INSERM, France
Sorbonne University, Pitié Salpêtrière Hospital APHP, France
Nutrition Unit, Regional University Hospital Centre, Tours, France
Dept. of Cardiology, CHU Martinique, University Hospital of Martinique, Fort de France, Martinique
Dept. of Nutrition, Gastroenterology Pediatric Unit, Trousseau Hospital (AP-HP), Sorbonne University, Paris, France
Hospices Civils de Lyon, Service de Gastroentérologie Hépatologie et Nutrition Pédiatrique, HFME, Bron, France
Service de Médecine Interne, Endocrinologie, Nutrition, Hôpital de Hautepierre, Strasbourg, France
Laboratory of Biochemistry and Molecular Genetics, Hospital Ambroise Paré-GHU APHP, Université Paris-Saclay, Boulogne-Billancourt, France
CHU de Bordeaux, Hôpital Haut-Lévêque, Pessac, France
Département dEndocrinologie, Diabète, Nutrition, CIC Inserm 1411, CHU de Montpellier, Montpellier, France
University Hospital Jean Minjoz, Dept. of Cardiology, Besançon, France
Service Endocrinologie, Diabétologie et Maladies Métaboliques, Hôpital du Bocage, Dijon, France
Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France, CHU de Lille, Lille, France
Dept. of Endocrinology, Diabetes and Nutrition, Hôpital Brabois Adultes, CHRU de Nancy, Vandoeuvre Lès Nancy, France
Centre for Internal Medicine with Gastroenterology and Nephrology, Lipid Clinic, Charité Berlin, Germany
MVZ Fachbereich Endokrinologie, Diabetologie, Adipositas und Lipide, Universitätsklinikum Eppendorf, Hamburg, Germany
Beckenbauer & Maierhof, Bremen, Germany
Clinic of Internal Medicine, Lipid Clinic, Klinikum Links der Weser, Bremen, Germany
Polyclinic for Endocrinology, Diabetes, and Preventive Medicine, University of Cologne, Germany
Medical Clinic D, Lipid Clinic, University Hospital Münster, Germany
Reha-Klinik Königsfeld, Ennepetal, Germany
Bensheim, Germany
Prevention First, Frankfurt a.M., Germany
Diabetologische Schwerpunktpraxis Speyer, Germany
Median Park-Klinik, Bad Dürkheim, Germany
Mannheim, Germany
Nierenzentrum Mannheim, Germany
Lanzgarten, Mannheim, Germany
Hirschberg-Großsachsen, Germany
Weinheim, Germany
Böblingen, Germany
Schwetzingen, Germany
Klinik für Endokrinologie, Stoffwechsel, Klinische Chemie Universitätsklinikum, Heidelberg, Germany
Ethianum, Heidelberg, Germany
Heilbronn, Germany
Dialysezentrum Bruchsal-Bretten, Bruchsal, Germany
Noxygen Science GmbH, Elzach, Germany
Panorama-Praxis, Marbach, Germany
Praxiszentrum Wiehre, Germany
Lipid Clinic University Clinic, Würzburg, Germany
Adelsried, Germany
Medical Clinic and Polyclinic IV, Ludwig-Maximilian University, Munich, Germany
Lipid Clinic, Clinic and Policlinic for Internal Medicine II, University Clinic Regensburg, Germany
Cardiology Am Weißen Turm, Nürnberg, Germany
Cardiopulmonale Schwerpunktpraxis, Nürnberg, Germany
Clinic and Policlinic for Cardiology, Dept. for Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Germany
Berlin, Germany
Rehazentrum Westend, Berlin, Germany
Helle Mitte, Berlin, Germany
KfH-Nierenzentrum Berlin-Köpenick, Berlin, Germany
Medicover Berlin-Mitte, Berlin, Germany
Dept. of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany
MVZ Stoffwechselmedizin Leipzig, Germany
Mühlhausen, Germany
1st Dept. of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece
1st Propedeutic Dept. of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
Dept. of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece
Dept. of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital Thessaloniki, Thessaloniki, Greece
Dept. of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece
Cardiology Clinic, University General Hospital of Heraklion, Heraklion, Greece
Metropolitan Hospital, Cardiometabolic Center, Lipoprotein Apheresis and Lipid Disorders Clinic, Athens, Greece
Cardiology Clinic, Onassis Cardiac Surgery Centre, Athens, Greece
Dept. of Pediatrics, Medical School, National and Kapodistrian University of Athens, 2ndPediatrics Clinic, General Childrens Hospital Pan. & Aglaia Kyriakou, Athens, Greece
Cardiology Clinic, Tzaneio General Hospital, Piraeus, Greece
Dept. of Pediatrics, Medical School, National and Kapodistrian University of Athens, C Pediatrics Clinic, Attikon University General Hospital, Athens, Greece
Dept. of Internal Medicine, 424 Military Hospital, Thessaloniki, Greece
Dept. of Endocrinology, Police Medical Centre of Thessaloniki, Thessaloniki, Greece
1st Dept. of Medicine, University of Pécs, Pécs, Hungary
Metabolic Centre, Szent Imre University Teaching Hospital, Budapest, Hungary
2nd Dept. of Medicine e Cardiology, Pandy Kalman Bekes County Hospital, Gyula, Hungary
1st Dept. of Internal Medicine Cardiology/Nephrology, Balassa János County Hospital, Szekszárd, Hungary
Fejér County St György Teaching Hospital, Székesfehérvár, Hungary
Borsod-Abaúj-Zemplén County University Teaching Hospital, Miskolc, Hungary
1st Dept. of Internal Medicine, Bács-Kiskun County Hospital-Cardiology, Kecskemét, Hungary
Kokilaben Dhidubhai Ambani Hospital and Medical Research Institute, Mumbai, India
Sir Ganga Ram Hospital, New Delhi, India
Elemamayn Al Kadhimayin Medical City, Iraq
Ministry of Health Ibn AlNafees Hospital, Iraq
Ministry of Health, Kurdistan, Erbil, Iraq
Rizgary Hospital, Iraq
Ministry of Health Diwaniya Hospital, Iraq
Ministry of Health, Balad Hospital, Salahaldeen, Iraq
Al-Mamorah Scientific Bureau, Iraq
Tallaght University Hospital, Ireland
Bert W. Strassburger Lipid Centre, Chaim Sheba Medical Centre, Tel Hashomer, Israel
Rabin Medical Centre, Petah Tikva, Israel
Dept. of Medicine, Wolfson Medical Centre, Holon, Israel
Dept. of Cardiology, Soroka University Medical Centre, Beer-Sheva, Israel
Diabetes and Metabolic Disease Unit, Kaplan Medical Centre, Rehovot, Israel
Dept. of Metabolic Clinic, Tel Aviv Medical Centre, Tel Aviv, Israel
Epidemiology and Preventive Pharmacology Service SEFAP, Dept. of Pharmacological and Biomolecular Sciences, University of Milan, Italy
IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy
Centre for the Study of Atherosclerosis E.Bassini, Cinisello Balsamo, Milano, Italy
Clinica di Medicina Interna e Geriatria, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, IRCCS-INRCA, Ancona, Italy
Centro Ipertensione Arteriosa e Prevenzione, Cardiovascolare UOC Medicina Interna e Nefrologia, Università dellAquila, Dipartimento MeSVA, Ospedale San Salvatore, lAquila, Italy
Soc Diabetologia e Malattie metaboliche, ASL AT, Asti, Italy
U.O. di Medicina Interna e Geriatria C. Frugoni, Centro di Assistenza e Ricerca Malattie Rare, A.O. Universitaria Policlinico Consorziale, Università degli Studi di Bari Aldo Moro, Bari, Italy
U.O.C. Malattie Endocrine, Centro regionale per il Diabete Diabetologia, Ospedale Treviglio-Caravaggiodi Treviglio, Treviglio, Italy
U.O. di Medicina Interna Cardiovascolare, Centro aterosclerosi, Ambulatorio dislipidemie, IRCCS S. Orsola Ospedale Policlinico S. Orsola-Malpighi, Bologna, Italy
Dipartimento di Scienze Biomediche, Università degli Studi di Cagliari, Centro per le Malattie Dismetaboliche e lArteriosclerosi, Associazione ME.DI.CO Onlus, Cagliari, Italy
Clinica Medica, Centro di Alta Specializzazione per la Prevenzione dellArteriosclerosi Centro di Eccellenza ESH per lIpertensione Arteriosa, Centro di Riferimento Regionale per le Dislipemie, Ospedale Policlinico S.S.Annunziata, Chieti, Italy
U.O. Medicina Interna Ospedale Garibaldi Nesima, Catania, Italy
A.O.U. Mater Domini, Catanzaro. OC di Nutrizione Clinica, Ambulatorio Dislipidemie, Catanzaro, Italy
U. O Medicina Interna Universitaria, Centro per lo Studio delle Dislipidemie e dellAterosclerosi, Azienda Ospedaliero-Universitaria di Ferrara, Polo di Cona, Ferrara, Italy
Dipartimento Medicina Sperimentale e Clinica, Università di Firenze, AOUC Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy
UOSD Prevenzione Cardiovascolare, Dipartimento di Scienze Mediche, Azienda Sanitaria Locale Frosinone, Frosinone, Italy
IRCCS Ospedale policlinico San Martino UOSD Dietetica e Nutrizione Clinica, Dipartimento di Medicina Interna, Università di Genova, Genova, Italy
Dipartimento di Medicina Clinica e Sperimentale, Centro per la Diagnosi e Cura della Dislipidemia e Prevenzione dellAterosclerosi, A.O. Universitaria Policlinico G. Martino, Messina, Italy
Centro per lo Studio dellAterosclerosi IRCCS Multimedica, Sesto San Giovanni, Italy
Centro Dislipidemie, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
Ambulatorio Dislipidemie, Centro per lo Studio e la Prevenzione dellArteriosclerosi, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico di Milano, Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milano, Italy
ASST-Rhodense Garbagnate Milanese, Garbagnate Milanese, Italy
U.O. Clinica Pediatrica, Servizio Clinico Dislipidemie per lo Studio e la Prevenzione dellAterosclerosi in Età Pediatrica, ASST-Santi Paolo e Carlo, Milano, Italy
U.O. Ambulatorio Prevenzione Aterosclerosi, IRCCS Cardiologico Monzino, Milano, Italy
Istituto Auxologico Italiano, Milano, Italy
U.O. Medicina Interna ad Indirizzo Metabolico-Nutrizionistico, Centro Dislipidemie e Malattie Metaboliche Rare, Ospedale Civile Baggiovara, AOU di Modena, Modena, Italy
U.O.C. Pediatria, Azienda Ospedaliero Universitaria di Modena, Modena, Italy
U.O. Medicina Interna 2, Centro per le Malattie da Arteriosclerosi, AORN Cardarelli, Napoli, Italy
Centro Coordinamento Regionale per le Iperlipidemie, AOU Policlinico Federico II, Napoli, Italy
Dipartimento di Scienze Mediche Traslazionali, Universita della Campania Luigi Vanvitelli, A.O. dei Colli Monaldi, Caserta, Italy
UO Medicina Interna e Malattie Metaboliche, Centro di Riferimento Regionale per la Prevenzione, Diagnosi e Cura delle Malattie Rare del Metabolismo e delle Dislipidemie Genetiche, A.O.U. Policlinico P. Giaccone, Palermo, Italy
Centro Dislipidemie in Età evolutiva U.O. Pediatria e Neonatologia, Ospedale Guglielmo da Saliceto, Piacenza, Piacenza, Italy
U. O. Clinica Medica 1, Centro Dislipidemie e Aterosclerosi, A.O. di Padova, Padova, Italy
U.O. Medicina Interna Angiologia, Malattie da Arteriosclerosi, Ambulatorio di Malattie del Ricambio Lipidico, Ospedale Santa Maria della Misericordia, Perugia, Italy
Arcispedale S. Maria Nuova, Azienda Ospedaliera di Reggio Emilia, Reggio Emilia, Italy
Dipartimento di Medicina Traslazionale e di Precisione, Sapienza Università di Roma, A.O. Policlinico Umberto I, Roma, Italy
Dipartimento di Medicina dei Sistemi, Università di Roma Tor Vergata, Roma, Italy
Dipartimento Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università, A.O. Policlinico Umberto I, Roma, Italy
UO Malattie Rare e Genetica Medica, Ospedale Pediatrico Bambino Ge

Imperial Centre for Cardiovascular Disease Prevention
Centre for Cardiovascular Surgery and Transplantation
Department of Vascular Medicine
Fundación Hipercolesterolemia Familiar
Carbohydrate and Lipid Metabolism Research Unit
Heart Institute (InCor)
Manchester University NHS Foundation Trust
School of Medicine
Lipid Disorders Clinic
Laboratory of Biochemistry and Molecular Therapeutics
Unidad de Investigación de Enfermedades Metabólicas
Tecnológico de Monterrey
Department of Cardiac Sciences
Faculty of Medicine
Heart and Vascular Institute
Cardiovascular Prevention Unit
Center for Advanced Metabolic Medicine and Nutrition
Department of Biochemistry
Sabah Al Ahmad Cardiac Centre
Gulf Diabetes and Endocrine Centre
Portuguese Atherosclerosis Society
P D Hinduja Hospital
Department of Hypertension
Cardiovascular Research Centre
Assistance Publique-Hôpitaux de Marseille
Department of Clinical Biochemistry
Department of Laboratory Medicine
National Advisory Unit on Familial Hypercholesterolemia
Unidade de Investigação e Desenvolvimento
Biosystems & Integrative Sciences Institute
1st Department of Cardiology Medical University of Gdańsk
FASTA University
Research Health Institute
Centre de Recherche Médicale de Jolimont
Cardiology Department
National Medical Research Centre of Cardiology
Universitatea de Medicina si Farmacie Victor Babes
Research Institute
Department of Pediatric Endocrinology
University of Ljubljana
National Cerebral and Cardiovascular Centre Research Institute
Department of Cardiology
Department of Medicine
Faculty of Medicine
Research Institute of Cardiology and Regenerative Medicine
Klinik und Poliklinik für Kardiologie
Department of Internal Medicine
Atherothrombosis Research Centre
Universidad de Oriente
Beijing Anzhen Hospital Capital Medical University
Advanced Lipid Management and Research Centre (ALMAR)
University of Cape Town Health Science Faculty
DACH Society for the Prevention of Heart and Circulatory Diseases
Department of Internal Medicine V
Klinisches Institut für Medizinische und Chemische Labordiagnostik
Synlab Akademie
Kyrgyz State Medical Academy
Diagene Research Institute
Faculty of Medicine
Dyslipidaemia Department
Institute of Pathology
Herlev and Gentofte Hospital
Cyprus International Institute for Environmental and Public Health
Department of Internal Medicine
Vilnius University Faculty of Medicine
Cantonal Hospital Zenica
Medical University of Sofia
Coordination Centre for Familial Hyperlipidemias
Cardiology Department
Department of Internal Medicine
Directorate of Research
Department of Child Health
Clinic for Heart and Circulatory Diseases
German Centre for Cardiovascular Research
Coronary Heart Disease and Atherosclerosis Department
GENYCO Program
Departments of Internal Medicine and Environmental and Occupational Medicine
Admiralty Medical Centre and Khoo Teck Puat Hospital
Academy for Postgraduate Medical Education
Lipid Clinic
Department of Medicine
Faculty of Medicine
Vietnam National Heart Institute
Facultad de Medicina
North Estonia Medical Centre
Beijing Anzhen Hospital
Rinku General Medical Centre
Department of Cardiology
Centre of Epidemiology and Preventive Pharmacology
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica
Dept. of Laboratory Medicine
Heart Institute InCor
McGill University
Dept. of Internal Medicine
Centre for Cardiovascular Surgery and Transplantation
Medical Faculty
Dept. of Clinical Biochemistry
Dept. of Clinical Medicine
Cardiology Dept.
Sorbonne University
Dept. of Internal Medicine
Dept. of Internal Medicine
Dept of vascular medicine
Dept. of Child Health
National Advisory Unit on FH
Medical Research Center
Dept. of Biochemistry
Shifa Tameer-e-Millat University
Cardiovascular Prevention Unit
Dept. of Pediatric Endocrinology
Dept. of Medicine
Dept. of Cardiology
Dyslipidaemia Dept.
Manchester University NHS Foundation Trust
Coronary Heart Disease and Atherosclerosis Dept.
Lab. of Lipids and Atherosclerosis
School of Medicine
Dept. of Internal Medicine I
Institute of Genetic Epidemiology
Austrian Atherosclerosis Society
Division of Endocrinology & Metabolism
Dept. of Pediatrics & Adolescent Medicine
Division of Cardiology
Division of Endocrinology and Diabetology
Austrian Academic Institute for Nutritional Medicine
Dept. of Endocrinology and Nephrologie
Dept. of Cardiology
Dept. of Diabetology
Dept. of Endocrinology
Dept. of Internal Medicine I
Dept. of Pediatrics
Dept. of Pediatrics I
Vivit Institute
Dept. of Laboratory Medicine
Centres Hospitaliers Jolimont
University Clinical Center Sarajevo
Dept. of Angiology and Electrophysiology
University Hospital Queen Joanna
Dept. of Cardiology
Dept. of Cardiology
Dept. of Cardiology
Dept. of Cardiology
CHU de Québec-Université Laval
Université de Montreal
Ecogene-21
University of British Columbia
Western University
University of Toronto
Montreal Clinical Research Institute
Clínica Las Condes
Beijing Institute of Genomics
Dept. of Cardiology
Dept. of Ultrasound
Dept. of Radiology
Dept. of Cardiology
Dept. of Endocrinology and Metabolism
Dept. of Emergency
Dept. of Cardiology
Dept. of Paediatrics
Dept. of Cardiology
Dept. of Cardiology
Dept. of Cardiology
Dept. of Emergency
Dept. of Radiology
Dept. of Nuclear Medicine
Dept. of Clinical Laboratory
Dept. of Laboratory Medicine
The Chinese University of Hong Kong
Dept. of Internal Medicine
Hippocrateon Private Hospital
Dept. of Pharmacy
General University Hospital
St. Annes University Hospital
Centre of Molecular Biology and Gene Therapy
Institute for Clinical and Experimental Medicine
Thomayer Hospital
University Hospital Kralovske Vinohrady
University Hospital Motol
Hospital Na Homolce
University Hospital
University Hospital
University Hospital
Lipid Outpatient Clinic
Regional Hospital Ceske Budejovice
Hospital Pisek
Outpatient Interkrim Clinics
Regional Hospital Liberec
Regional Hospital Trutnov
Hospital Jablonec nad Nisou
Regional Hospital Jicin
Hospital of the Pardubice Region
Edumed
Regional T. Bata Hospital
Ormiga Medical House
Lipid Outpatient Clinics
Hospital Trebic
Hospital Vyskov
Outpatient Mephacentrum Clinics
Ostrava City Hospital
Hospital Frydek-Mistek
Hospital Krnov
Dept. of Clinical Biochemistry
Dept. of Clinical Medicine
Benha University
Italian Hospital
Military Medical Academy
Port-Foad Cardiac Centre
Alexandria University
National Heart Institute
Cairo University
Hayat Hospital
Cairo University
Tallinn University of Technology
Tours University
APHM
AP-HP
LInstitut du Thorax
La Pitié Salpêtrière hospital APHP
Sorbonne University
Hospices Civils de Lyon
Dept. of Cardiology
Dept. of Biochemistry and Molecular Biology
Internal Medicine Dept.
CHU Pontchaillou
Pôle Thoracique / Cardiaque / Vasculaire
Lipid Clinic
Dept. of Cardiology
Toulouse Rangueil University Hospital
Sorbonne University
Nutrition Unit
Dept. of Cardiology
Dept. of Nutrition
Hospices Civils de Lyon
Service de Médecine Interne
Laboratory of Biochemistry and Molecular Genetics
CHU de Bordeaux
Département dEndocrinologie
University Hospital Jean Minjoz
Service Endocrinologie
Département de Médecine Interne et Immunologie Clinique
Dept. of Endocrinology
Centre for Internal Medicine with Gastroenterology and Nephrology
MVZ Fachbereich Endokrinologie
Beckenbauer & Maierhof
Clinic of Internal Medicine
Polyclinic for Endocrinology
Medical Clinic D
Reha-Klinik Königsfeld
Bensheim
Prevention First
Diabetologische Schwerpunktpraxis Speyer
Median Park-Klinik
Mannheim
Nierenzentrum Mannheim
Lanzgarten
Hirschberg-Großsachsen
Weinheim
Böblingen
Schwetzingen
Klinik für Endokrinologie
Ethianum
Heilbronn
Dialysezentrum Bruchsal-Bretten
Noxygen Science GmbH
Panorama-Praxis
Praxiszentrum Wiehre
Lipid Clinic University Clinic
Adelsried
Medical Clinic and Polyclinic IV
Lipid Clinic
Cardiology Am Weißen Turm
Cardiopulmonale Schwerpunktpraxis
Clinic and Policlinic for Cardiology
Berlin
Rehazentrum Westend
Helle Mitte
KfH-Nierenzentrum Berlin-Köpenick
Medicover Berlin-Mitte
Dept. of Internal Medicine III
MVZ Stoffwechselmedizin Leipzig
Mühlhausen
1st Dept. of Cardiology
1st Propedeutic Dept. of Internal Medicine
Dept. of Cardiology
Dept. of Internal Medicine
Dept. of Internal Medicine
Cardiology Clinic
Metropolitan Hospital
Cardiology Clinic
Dept. of Pediatrics
Cardiology Clinic
Dept. of Pediatrics
Dept. of Internal Medicine
Dept. of Endocrinology
1st Dept. of Medicine
Metabolic Centre
2nd Dept. of Medicine e Cardiology
1st Dept. of Internal Medicine Cardiology/Nephrology
Fejér County St György Teaching Hospital
Borsod-Abaúj-Zemplén County University Teaching Hospital
1st Dept. of Internal Medicine
Kokilaben Dhidubhai Ambani Hospital and Medical Research Institute
Sir Ganga Ram Hospital
Elemamayn Al Kadhimayin Medical City
Ministry of Health Ibn AlNafees Hospital
Ministry of Health
Rizgary Hospital
Ministry of Health Diwaniya Hospital
Ministry of Health
Al-Mamorah Scientific Bureau
Tallaght University Hospital
Bert W. Strassburger Lipid Centre
Rabin Medical Centre
Dept. of Medicine
Dept. of Cardiology
Diabetes and Metabolic Disease Unit
Dept. of Metabolic Clinic
Epidemiology and Preventive Pharmacology Service SEFAP
IRCCS MultiMedica
Centre for the Study of Atherosclerosis E.Bassini
Clinica di Medicina Interna e Geriatria
Centro Ipertensione Arteriosa e Prevenzione
Soc Diabetologia e Malattie metaboliche
U.O. di Medicina Interna e Geriatria C. Frugoni
U.O.C. Malattie Endocrine
U.O. di Medicina Interna Cardiovascolare
Dipartimento di Scienze Biomediche
Clinica Medica
U.O. Medicina Interna Ospedale Garibaldi Nesima
A.O.U. Mater Domini
U. O Medicina Interna Universitaria
Dipartimento Medicina Sperimentale e Clinica
UOSD Prevenzione Cardiovascolare
IRCCS Ospedale policlinico San Martino UOSD Dietetica e Nutrizione Clinica
Dipartimento di Medicina Clinica e Sperimentale
Centro per lo Studio dellAterosclerosi IRCCS Multimedica
Centro Dislipidemie
Ambulatorio Dislipidemie
ASST-Rhodense Garbagnate Milanese
U.O. Clinica Pediatrica
U.O. Ambulatorio Prevenzione Aterosclerosi
Istituto Auxologico Italiano
U.O. Medicina Interna ad Indirizzo Metabolico-Nutrizionistico
U.O.C. Pediatria
U.O. Medicina Interna 2
Centro Coordinamento Regionale per le Iperlipidemie
Dipartimento di Scienze Mediche Traslazionali
UO Medicina Interna e Malattie Metaboliche
Centro Dislipidemie in Età evolutiva U.O. Pediatria e Neonatologia
U. O. Clinica Medica 1
U.O. Medicina Interna Angiologia
Arcispedale S. Maria Nuova
Dipartimento di Medicina Traslazionale e di Precisione
Dipartimento di Medicina dei Sistemi
Dipartimento Scienze Cliniche
UO Malattie Rare e Genetica Medica

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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026