Patient-specific variables determine the extent of cellular senescence biomarkers in ovarian tumors in vivo
Uruski P. Mikuła-Pietrasik J. Naumowicz E. Kaźmierczak K. Gaiday A.N. Królak J. Nowakowski B. Moszyński R. Tykarski A. Ksiażek K.
April 2021MDPI AG
Biomedicines
2021#9Issue 4
The mechanisms and clinical significance of the cellular senescence of tumor cells are a matter of ongoing debate. Recently, the triggers and molecular events underlying spontaneous, replicative senescence of primary epithelial ovarian cancer cells were characterized. In this study, we reanalyzed tumors obtained from ovarian cancer patients with respect to the expression of the senescence biomarkers SA-β-Gal and γ-H2A.X and the proliferative antigen Ki67. The results showed that the tumors displayed strong heterogeneity with respect to the expression of analyzed markers. The expression of SA-β-Gal and γ-H2A.X in the oldest patients (61–85 y.o.) was significantly higher than in the younger age groups. Conversely, the area of Ki67-positive cancer cells was greater in younger individuals. At the same time, there was a positive correlation between SA-β-Gal expression and calendar age in FIGO III–IV and malignant ascites-positive patients. The γ-H2A.X positively correlated with age in the whole group, FIGO III–IV, and ascites-positive patients. Ki67 levels correlated negatively with the age of patients among those same groups. Collectively, our study indicated that organismal aging may determine the development of the senescence phenotype in ovarian tumors, particularly in patients with advanced disease and those accumulating malignant ascites.
Aging , Biomarkers , Cellular senescence , FIGO , Malignant ascites , Ovarian cancer
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Department of Hypertensiology, Poznań University of Medical Sciences, Poznań, 61-848, Poland
Department of Pathophysiology of Ageing and Civilization Diseases, Poznań University of Medical Sciences, Poznań, 61-848, Poland
General Surgery Ward, Medical Centre HCP, Poznan, 61-485, Poland
The Greater Poland Cancer Center, Department of Surgical, Oncological, and Endoscopic Gynecology, Poznań, 61-866, Poland
Department of Obstetrics and Gynecology, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030008, Kazakhstan
Division of Gynecological Surgery, Poznan University of Medical Sciences, Poznan, 60-535, Poland
Department of Hypertensiology
Department of Pathophysiology of Ageing and Civilization Diseases
General Surgery Ward
The Greater Poland Cancer Center
Department of Obstetrics and Gynecology
Division of Gynecological Surgery
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