All organic nanomedicine for PDT–PTT combination therapy of cancer cells in hypoxia
Urazaliyeva A. Kanabekova P. Beisenbayev A. Kulsharova G. Atabaev T. Kim S. Lim C.-K.
December 2024Nature Research
Scientific Reports
2024#14Issue 1
Photodynamic and photothermal therapies are promising treatments for cancer, dermatological, and ophthalmological conditions. However, photodynamic therapy (PDT) is less effective in oxygen-deficient tumor environments. Combining PDT with photothermal therapy (PTT) can enhance oxygen supply and treatment efficacy. Inorganic PTT agents pose toxicity risks, limiting their clinical use despite their high performance. In this study, we developed a novel nanomedicine integrating an all-organic photothermal agent and an organic photosensitizer, creating a colocalized nanoplatform to enhance phototherapy efficacy in cancer treatment. PTT nanoparticles (NPs) were synthesized through a thermal phase transition of organic chromophores, demonstrating superior photothermal properties and photostability. Utilizing this nanoplatform, we devised ‘Combi NPs’ for combined PDT–PTT nanomedicine. Tests on A549 cancer cell lines have revealed that Combi NPs exhibit superior cytotoxicity and induce apoptosis in hypoxic conditions, outperforming PTT-only NPs. The all-organic Combi NPs show significant potential for clinical cancer phototherapy in hypoxic microenvironments, potentially mitigating long-term nanomedicine accumulation and associated toxicity.
Combination therapy , Hypoxia , Nanomedicine , Photodynamic therapy , Photothermal therapy
Text of the article Перейти на текст статьи
Department of Chemical and Materials Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Electrical and Computer Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Chemistry, Nazarbayev University, Astana, 010000, Kazakhstan
Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, 02792, South Korea
Department of Chemical and Materials Engineering
Department of Electrical and Computer Engineering
Department of Chemistry
Chemical and Biological Integrative Research Center
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026