Dynamics of Sex Hormones in Men with Diabetes Mellitus After Autologous Mesenchymal Stem Cell Transplant
Ulyanova O. Askarov M. Baigenzhin A. Kozina L. Boltanova A. Serebrennikova D. Smelova A.
Jan 2024Baskent University
Experimental and Clinical Transplantation
2024#22Issue 1281 - 284 pp.
Objectives: Our goal was to determine levels of sex hormones in men with type 1 diabetes mellitus and type 2 diabetes mellitus after autologous mesenchymal stem cell transplant. Materials and Methods: We examined 10 male patients (32-56 years old) with type 1 diabetes mellitus and type 2 diabetes mellitus, whom we subsequently divided into 2 groups and examined. Group 1 comprised 5 male patients who received autologous mesenchymal stem cell transplant (cells were obtained from patient’s iliac crest and cultured for 3-4 weeks) by intravenous infusion. Group 2 comprised 5 male patients (control group) who were on hypoglycemic tablet therapy or insulin therapy. The quantity of autologous mesenchymal stem cells infused was 95 × 106 to 97 × 106 cells. We analyzed levels of testosterone, luteinizing hormone, estradiol, and glycated hemoglobin in patients both before and 3 months after the autologous mesenchymal stem cell transplant procedure. Results: In men with type 1 diabetes mellitus and type 2 diabetes mellitus, autologous mesenchymal stem cell transplant led to an increase in testosterone levels from 5.31 ± 2.12 to 6.33 ± 2.12 ng/mL (P =.82), a decrease in luteinizing hormone from 8.43 ± 1.25 to 5.94 ± 1.57 mIU/mL (P =.04), and a decrease in glycated hemoglobin from 9.45 ± 1.24% to 8.53 ± 1.08% (P =.25) after 3 months. The increase in testosterone in men with autologous mesenchymal stem cell transplant group of 6.33 ± 2.12 ng/mL was significant compared with men in the control group (3.9 ± 1.18 ng/mL; P =.01). Conclusions: Testosterone level increased and luteinizing hormone level decreased within 3 months after autologous mesenchymal stem cell transplant in men with diabetes mellitus.
Glycated hemoglobin , Pancreatic islet cell regeneration , Testosterone
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Department of Endocrine Disturbances, The National Scientific Medical Center, Astana, Kazakhstan
Department of Stem Cell Technologies, The National Scientific Medical Center, Astana, Kazakhstan
Department of Chairman of the Board, The National Scientific Medical Center, Astana, Kazakhstan
Department of Central Research Laboratory, The National Scientific Medical Center, Astana, Kazakhstan
Department of Endocrine Disturbances
Department of Stem Cell Technologies
Department of Chairman of the Board
Department of Central Research Laboratory
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