Comparative study of morphological changes in the kidney and ureter of a rabbit with various methods of infection
Tusupbekova M.M. Sharapatov Y.A. Pronkin E.A. Lavrinenko A.V. Turgunov Y.M.
30 March 2022MDV Group
Clinical and Experimental Morphology
2022#11Issue 162 - 72 pp.
Introduction. There are two main routes of urinary tract infection: ascending and hematogenous. In the ascending route, the infectious agent penetrates from the external environment through the external openings of the urinary organs. The role of bacterial translocation in the development of the inflammatory process in the urinary organs is still poorly understood. Materials and methods. We conducted an experiment on rabbits (n=45) and studied the structural changes in the kidneys and ureter depending on the pathogenesis of acute pyelonephritis. The animals were randomly divided into 5 groups: 2 experimental and 3 control. In experimental groups I and II, we modeled obstructive pyelonephritis by ligation of the ureter. In control groups III and IV, an infectious agent was administered similarly to that in the experimental groups, but without creating a model of obstructive pyelonephritis. In control group V, a laparotomy was performed without ligation of the ureter and without injection of bacteria. The morphological study was carried out with optical microscopy. Results. In group I, on day 3, the inflammatory infiltration was detected in 80% of cases and on day 5, in 100%. In group II, on days 3 and 5, the inflammatory process in the ureteral tissue developed in all cases. There were no morphological changes in the kidneys and ureter in groups III and V. In group IV, on days 3 and 5, the frequency of inflammatory infiltration was 80%. Conclusion. The nature of morphological changes in the kidneys and ureter in acute pyelonephritis depends on both the ways of infection and the timing of ureteral obstruction. In enterorenal translocation, the severity of morphological changes occurs later.
acute pyelonephritis , ascending infection , intestinal translocation , urinary tract obstruction
Text of the article Перейти на текст статьи
Medical University of Karaganda, Karaganda, Kazakhstan
Сentral State Medical Academy of Department of Presidential Affairs, Moscow, Russian Federation
Scientific Research Center of the Medical University of Karaganda, Karaganda, Kazakhstan
Medical University of Karaganda
Сentral State Medical Academy of Department of Presidential Affairs
Scientific Research Center of the Medical University of Karaganda
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026