The specifics of pregnancy management with thrombophilia: A clinical case
Tursynbayeva S.A. Medved V.I. Tyan I.I. Baimurzayeva L.G.
2024Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2024#2024Issue 3101 - 106 pp.
Relevance: Thrombophilia is an acquired and/or genetic condition predisposing people to thromboembolism. Thrombophilic disorders increase obstetric complications, such as early pregnancy loss, fetal growth retardation, placental abruption, and preeclampsia. Recurrent miscarriage (RM) is one of the most difficult and demanding areas of medicine due to the huge emotional burden placed on families with RM. Pregnancy management in women with habitual miscarriages associated with thrombophilia requires special attention. The study aimed to demonstrate the relationship between polymorphism genes of thrombophilia and obstetric complications by analyzing a clinical case of pregnancy in a patient with thrombophilia. Materials and Methods: The article describes a clinical case of a pregnant woman at 12 weeks of pregnancy with thrombophilia and aggravated obstetric and gynecological history. Results: In the described clinical case, the patient underwent genetic testing for a predisposition to thrombophilia, which revealed five polymorphisms indicating an average hereditary risk for thrombophilia. The administration of an adequate dose of acetylsalicylic acid and low molecular weight heparins led to full-term pregnancy. Conclusion: Multiple thrombophilia factors carry a significant additional risk of adverse outcomes for the mother and fetus. Early diagnosis of thrombophilia, genetic counseling, and gynecological monitoring can be very useful for preventing pregnancy complications in women with PNB, offering adequate treatment and prevention.
anticoagulant therapy , low molecular weight heparins , recurrent miscarriage , thrombophilia
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Kazakhstan’s Medical University “Kazakhstan School of Public Health”, Almaty, Kazakhstan
Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Institute of Reproductive Medicine, Almaty, Kazakhstan
Kazakhstan’s Medical University “Kazakhstan School of Public Health”
Institute of Pediatrics
Institute of Reproductive Medicine
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