The Association of Endothelin-1 with Early and Long-Term Mortality in COVID-19

Turgunova L. Mekhantseva I. Laryushina Y. Alina A. Bacheva I. Zhumadilova Z. Turmukhambetova A.
November 2023 Multidisciplinary Digital Publishing Institute (MDPI)

Journal of Personalized Medicine
2023 #13 Issue 11

(1) Background: Endothelial dysfunction is a key mechanism in the pathogenesis of COVID-19. High endothelin-1 during COVID-19 is associated with severe complications and increased mortality rates during hospitalization. This study is aimed to investigate the association of endothelin-1 levels with the risk of 30-day and 12-month all-cause mortality in patients with prior COVID-19. (2) Methods: A prospective study was conducted involving patients with COVID-19 in Karaganda, Kazakhstan. The level of endothelin-1 in the blood serum was evaluated by ELISA. Univariate and multivariate Cox regression was used to determine factors and significance of endothelin-1 associated with the risk of mortality within 30 and 365 days from hospitalization. (3) Results: The median endothelin-1 was higher in the group of patients who passed away within 30 days. The group showed statistically significant differences when compared to healthy volunteers from the control group (p = 0.0001), surviving patients (p = 0.001), and those who passed away within a year (p = 0.002). (4) Conclusions: Endothelin-1 levels are associated with increased mortality risk during the acute period of COVID-19, while plasma endothelin-1 level association with COVID-19 survivor mortality risk does not persist after 12 months.

COVID-19 , endothelial dysfunction , endothelin-1 , mortality

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Department of Internal Medicine, Karaganda Medical University, Karaganda, 100000, Kazakhstan

Department of Internal Medicine

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