Metabolic syndrome as a factor affecting on intima-media thickness in patients with rheumatoid arthritis

Turgunova L.G. Shalygina A.A. Ibrayeva L.K. Turmuhambetova A.A.
2021 Scientific Foundation SPIROSKI

Open Access Macedonian Journal of Medical Sciences
2021 #9 411 - 416 pp.

AIM: The aim of the study was to assess the association of the thickness of the intima-media complex with metabolic syndrome (MetS) and the degree of disease activity in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: The study included 101 patients with RA. All patients underwent a biochemical examination, the presence of MetS was determined, and the carotid thickness of the intima-media was determined. Statistical processing was performed using SPSS for Windows, version 18.0. RESULTS: Among 101 patients with RA, 41 (40.5%) had MetS. The frequency of detecting an increased value of the intima-media complex thickness was significantly higher in the group with MetS (n = 31 [75.6%]) than in the group without MetS (n = 21 [35.0%] p ≤ 0.0001). In the group of patients with MetS, the median carotid intima-media thickness (CIMT) was 1.2 mm, while this indicator in the group without MetS was 0.78 mm (U = 727, p = 0.001). In the regression model, MetS (B = 1.05; p = 0.027) and DAS28-ESR (B = 0.506; p = 0.021) were influenced by CIMT. CONCLUSIONS: The results of our study show the effect of MetS and RA activity on the increase of intima-media thickness.

Intima-media thickness , Metabolic syndrome , Rheumatoid arthritis

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Department of Internal Medicine, Karaganda Medical University, Karaganda, Kazakhstan
Karaganda Medical University, Karaganda, Kazakhstan
Department of Strategic Development, Karaganda Medical University, Research and International Collaboration, Karaganda, Kazakhstan

Department of Internal Medicine
Karaganda Medical University
Department of Strategic Development

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