Biomarkers of intestinal wall damage in multiple organ dysfunction syndrome
Turgunov Y.M. Ogizbayeva A.V. Mugazov M.M. Asamidanova S.G.
2024Media Sphera Publishing Group
Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya
2024#2024Issue 2114 - 120 pp.
Increased intestinal wall permeability and impaired barrier function in ICU patients are due to microcirculation disorders, ischemia and hypoxia of intestinal wall. As a result, bacteria and/or their endotoxins penetrate the damaged intestinal wall, enhance immune response and can lead to systemic inflammation, multiple organ dysfunction syndrome, sepsis and even death. This review is devoted to mechanisms of intestinal barrier disruption and the most effective serum biomarkers of intestinal wall damage: zonulin, intestinal fatty acid binding protein (I-FABP) and regenerating islet-derived 3-alpha (REG3α), citrulline. Despite various study limitations, these biomarkers are interesting candidates for identifying patients with high risk of complications and screening for timely intensive care measures. These approaches can reduce ICU-stay and mortality.
biomarkers of intestinal wall damage , citrulline , I-FABP , MODS , multiple organ dysfunction syndrome , REG3α , zonulin
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Karaganda Medical University, Karaganda, Kazakhstan
Karaganda Medical University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026