Synthesis and Antibacterial Activity of Hydrazones of Isonicotinic and Salicylic Acids Based on Acetyl Derivatives of Coumarin and Benzo[g][1,3,5]Oxadiazocine
Кумарин мен бензоg1,3,5оксадиазоцин ацетил туындылары негізінде изоникотин және салицил қышқылдары гидразондарының синтезі және бактерияғақарсы белсенділігі
Синтез и антибактериальная активность гидразонов изоникотиновой и салициловой кислот на основе ацетилпроизводных кумарина и бензоg1,3,5оксадиазоцина
Turgunalieva D.M. Dilbaryan D.S. Vasilchenko A.S. Kulakov I.V. Nurkenov O.A. Fazylov S.D. Karipova G.Z. Seilkhanov T.M.
2022E.A.Buketov Karaganda State University Publish House
Bulletin of the Karaganda University Chemistry Series
2022#108Issue 425 - 34 pp.
In recent decades, the efforts of many researchers in the sphere of organic chemistry, physics and pharmacology have been focused on the search for new agents with pronounced antibacterial and especially antifungal activity. This is due to the widespread increase in the resistance of many bacterial strains and fungi to antibiotics and antifungal drugs available in medical practice. In this regard, the number of works related to the synthesis of new potential antibiotics from the most diverse class of organic derivatives, which either include known pharmacophore groups or represent a new structural class of compounds with unknown and unexplored activity, is increasing in the scientific literature. In this work, new previously undescribed hydrazones derivatives were obtained on the basis of physiologically active isonicotinic and salicylic acid hydroxides and laboratory-available acetyl-substituted heterocycles, namely 3-acetyl-2H-chromen-2-one 3,2-acetyl-3H-benzo[f]chromen-3-one 4 and 2,6-methanobenzo[g][1,3,5]oxadiazocine 5. The obtained hydrazones structure is explicitly proved by IR and 1H, 13C NMR spectroscopy data. The synthesized six new hydrazones underwent biological screening for antibacterial and antifungal activity on strains of microorganisms, namely gram-positive bacterium Staphylococcus aureus 209P, gram-negative bacterium Pectobacterium carotovorum VKM-B1247, and yeast-like fungus Candida albicans ATCC 10231. Screening revealed three compounds with antimicrobial activity and one promising compound — (E)-2-hydroxy-N’-(1-(2-oxochroman-3-yl)ethylidene)benzohydrazide 9, which also exhibits antifungal activity along with antimicrobial activity.
2,6-methanobenzo[g][1,3,5]oxadiazocine , 2-acetyl-3H-benzo[f]chromen-3-one , 3-acetyl-2H-chromen-2-one , antimicrobial activity , coumarins , hydrazides , hydrazones , isoniazid , salicylic acid hydrazide
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Institute of Chemistry, University of Tyumen, Perekopskaya St., 15a, Tyumen, 625003, Russian Federation
Laboratory of Antimicrobial Resistance, Institute of Environmental and Agricultural Biology (X-BIO), University of Tyumen, Lenina St., 23, Tyumen, 625003, Russian Federation
Biological Sciences, Laboratory of Antimicrobial Resistance, Institute of Environmental and Agricultural Biology (X-BIO), University of Tyumen, Lenina St., 23, Tyumen, 625003, Russian Federation
Chemical Sciences, Institute of Chemistry, University of Tyumen, Perekopskaya St., 15a, Tyumen, 625003, Russian Federation
Chemical Sciences, LLP Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Alikhanov str., 1, Karaganda, 100000, Kazakhstan
Academician of the National Academy of Sciences of the Republic of Kazakhstan, Chemical Sciences, LLP Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Alikhanov str., 1, Karaganda, 100000, Kazakhstan
LLP Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Alikhanov str., 1, Karaganda, 100000, Kazakhstan
Chemical Sciences, The laboratory of Engineering Profile NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, Abay str., 76, Kokshetau, 020000, Kazakhstan
Institute of Chemistry
Laboratory of Antimicrobial Resistance
Biological Sciences
Chemical Sciences
Chemical Sciences
Academician of the National Academy of Sciences of the Republic of Kazakhstan
LLP Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Chemical Sciences
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