Synthesis, Structure Characterization, and Antimicrobial Activity Of 2-Amino-3-[(2-Amino-2-Carboxyethyl) Disulfanyl] Propanoic Acid Dihydrogen Triiodide Coordination Compound
Turganbay S. Ilin A. Atageldiyeva N. Jumagaziyeva A. Kenesheva S. Baigaipova G. Mun S.
October 2023Engineered Science Publisher
Engineered Science
2023#25
The aim of this study was the synthesis of iodine coordination compounds for the treatment of nosocomial infections caused by drug-resistant bacteria. A new 2-amino-3-[(2-amino-2-carboxyethyl) disulfanyl] propanoic acid dihydrogen triiodide coordination compound was synthesized in basic and water media with a stoichiometric ratio of 1:2:2 of Cystine:LiI:iodine. The physico-chemical properties of complex 2-amino-3-[(2-amino-2-carboxyethyl) disulfanyl] propanoic acid dihydrogen triiodide were examined. Obtained crystals were studied by single-crystal X-ray diffraction, FTIR spectroscopy, UV-Vis spectrophotometer and Thermogravimetry/Differential Scanning Colorimeter (TG/DSC). The compound crystallizes in the orthorhombic P212121 with lattice parameters a = 9.5739(19) Å, b = 13.558(3) Å, c = 16.405(3) Å, α = 90, β = 90, γ = 90, V = 2129.4(7) Å3; Z = 4. The antimicrobial activity of the synthesized compound was investigated. Activity evaluations were done against ATCC bacterial and clinical isolates, including WHO-prioritised drug-resistant strains. In the study, the effectiveness of a new coordination compound of iodine against bacteria with multidrug resistance was shown. This fact, as well as the semiorganic nature of the compound, determine the prospects for its use in medicine as an antimicrobial agent.
Antimicrobial activity , Crystal structure , Cystine , Iodine , X-ray diffraction analysis
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JSC Scientific Center for Anti-Infectious Drugs, Almaty, 050060, Kazakhstan
Kazakh-British Technical University, Almaty, 050000, Kazakhstan
JSC Scientific Center for Anti-Infectious Drugs
Kazakh-British Technical University
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