Synthesis, physicochemical properties and antimicrobial activity of a di-aminopropionic acid hydrogen tri-iodide coordination compound
Turganbay S. Kenesheva S. Jumagaziyeva А. Ilin A. Askarova D. Azembayev A. Kurmanaliyeva A.
December 2024BioMed Central Ltd
BMC Research Notes
2024#17Issue 1
Objective: The objective of this study is to synthesize and comprehensively characterize a novel iodine-containing coordination compound, di-aminopropionic acid hydrogen tri-iodide. This involves determining its structural, physicochemical, and thermal properties, as well as evaluating its antimicrobial activity against a range of bacterial strains, including multidrug-resistant pathogens. The aim is to explore the potential of this compound as a candidate for developing new antibacterial agents to address the challenge of antibiotic resistance. Results: An original iodine-containing semiorganic coordination compound was synthesized and characterized. The physicochemical properties were studied via diffraction, FTIR spectroscopy and thermogravimetric/differential scanning calorimetry (TG/DSC). In vitro antimicrobial activity evaluation was performed using two-fold serial dilution method. The obtained results demonstrated efficiency against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii) bacteria including MDR strains that cause infectious disease. The results of the antibacterial evaluation revealed that the new iodine coordination compound – di-aminopropionic acid hydrogen tri-iodide possesses high bactericidal properties and exhibits better antimicrobial activity against both susceptible and multidrug-resistant strains than does Lugol solution and ampicillin sodium, which are used as reference drugs.
Alanine , Antimicrobial activity, multidrug resistance , Coordination compound , Iodine
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Laboratory of New Substances and Materials, JSC Scientific Center for Anti-Infectious Drugs, Almaty, 050060, Kazakhstan
“One Belt One Road” Petroleum Engineering Institute, Kazakh-British Technical University, Almaty, 050000, Kazakhstan
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Laboratory of New Substances and Materials
“One Belt One Road” Petroleum Engineering Institute
Faculty of Biology and Biotechnology
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