Mechanochemical Synthesis of Hydrophilic Sulfur Nanoparticles in Aqueous Surfactant Solutions and Their Antibacterial Activity and Acute Toxicity in Mice
Turganbay S. Aidarova S. Kumargaliyeva S. Argimbayev D. Sabitov A. Iskakbayeva Z. Lyu M. Ibragimova N. Turganbay G.
March 2024Engineered Science Publisher
ES Materials and Manufacturing
2024#23
Sulfur is an abundantly available biologically active element and has been used for a long time as a bactericidal and fungicidal drug in both medical, veterinary and in agricultural practices. Synthesized hydrophilic sulfur nanoparticles can potentially allow the delivery of high concentrations of sulfur to infections. In the present study, a quick and environmentally friendly approach has been developed for the synthesis of hydrophilic sulfur nanoparticles with antibacterial activity. Hydrophilic sulfur nanoparticles (SNPs) were prepared by modifying the surface of elemental sulfur by various water-soluble surfactants including hexadecyltrimethylammonium bromide (CTAB), sodium dodecyl benzene sulfonate (SDBS) and Triton X-100 (TX-100). The hydrophilic SNPs were characterized by UV–visible spectrophotometer, X-ray diffraction (XRD), and thermogravimetric analysis (TG/DSC), scanning electron microscope (SEM), the hydrophilic SNPs showed an almost spherical shape with an average size in the range of 150-200 nm. The antibacterial activity of the hydrophilic sulfur nanoparticles was tested using against Gram-positive (S. aureus and E. faecium) and Gram-negative (E. coli and P. aeruginosa) bacteria. As a result, that hydrophilic SNPs exhibited significant antimicrobial activity against Gram-positive bacteria, i.e., S. aureus and E. faecium. The acute toxicity of the hydrophilic SNPs was studied at a single oral administration of solutions of hydrophilic SNPs, as a result of the study of hydrophilic SNPs, it was determined as a non-toxic substance. The received products can be considered as perspective forms of application in agriculture and medicine.
Acute toxicity , Antibacterial , Hydrophilic sulfur nanoparticles , Mechanochemical synthesis , Surfactant
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Kazakh-British Technical University, One Belt, One Road Petroleum Engineering, Almaty, 050000, Kazakhstan
JSC Scientific Center for Anti-Infectious Drugs, Laboratory of New Substances and Materials, Almaty, 050060, Kazakhstan
Al-Farabi Kazakh National University, Department of Analytical, Colloidal Chemistry and Technology of Rare Elements, Almaty, 050000, Kazakhstan
Institute of Combustion Problems, Nanobiotechnology Laboratory, Almaty, 050012, Kazakhstan
Kazakh National Agrarian University, Agronomy, Breeding and Biotechnology, Almaty, 050000, Kazakhstan
Kazakh-British Technical University
JSC Scientific Center for Anti-Infectious Drugs
Al-Farabi Kazakh National University
Institute of Combustion Problems
Kazakh National Agrarian University
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